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RPR 119990, a novel alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid antagonist: synthesis, pharmacological properties, and activity in an animal model of amyotrophic lateral sclerosis.
Canton T, Böhme GA, Boireau A, Bordier F, Mignani S, Jimonet P, Jahn G, Alavijeh M, Stygall J, Roberts S, Brealey C, Vuilhorgne M, Debono MW, Le Guern S, Laville M, Briet D, Roux M, Stutzmann JM, Pratt J. Canton T, et al. Among authors: brealey c. J Pharmacol Exp Ther. 2001 Oct;299(1):314-22. J Pharmacol Exp Ther. 2001. PMID: 11561094
An S-warfarin and AZD1981 interaction: in vitro and clinical pilot data suggest the N-deacetylated amino acid metabolite as the primary perpetrator.
Grime K, Pehrson R, Nordell P, Gillen M, Kühn W, Mant T, Brännström M, Svanberg P, Jones B, Brealey C. Grime K, et al. Among authors: brealey c. Br J Clin Pharmacol. 2017 Feb;83(2):381-392. doi: 10.1111/bcp.13102. Epub 2016 Oct 13. Br J Clin Pharmacol. 2017. PMID: 27558866 Free PMC article. Clinical Trial.
Effects of CYP3A4 Inhibitors Ketoconazole and Verapamil and the CYP3A4 Inducer Rifampicin on the Pharmacokinetic Parameters of Fostamatinib: Results from In Vitro and Phase I Clinical Studies.
Martin P, Gillen M, Millson D, Oliver S, Brealey C, Grossbard EB, Baluom M, Lau D, Sweeny D, Mant T, Craven K. Martin P, et al. Among authors: brealey c. Drugs R D. 2016 Mar;16(1):81-92. doi: 10.1007/s40268-015-0118-4. Drugs R D. 2016. PMID: 26739683 Free PMC article. Clinical Trial.
Toxicity of pesticides to birds; the enzymic factor.
Walker CH, Brealey CJ, Mackness MI, Johnston G. Walker CH, et al. Among authors: brealey cj. Biochem Soc Trans. 1991 Aug;19(3):741-5. doi: 10.1042/bst0190741. Biochem Soc Trans. 1991. PMID: 1664395 Review. No abstract available.
12 results