Lockey P - Search Results

1

Selective endothelin A receptor antagonists. 4. Discovery and structure-activity relationships of stilbene acid and alcohol derivatives.

Astles PC, Brown TJ, Halley F, Handscombe CM, Harris NV, McCarthy C, McLay IM, Lockey P, Majid T, Porter B, Roach AG, Smith C, Walsh R. Astles PC, et al. Among authors: lockey p. J Med Chem. 1998 Jul 16;41(15):2745-53. doi: 10.1021/jm970847e. J Med Chem. 1998. PMID: 9667965

2

Identification of a non peptidic RANTES antagonist.

Bright C, Brown TJ, Cox P, Halley F, Lockey P, McLay IM, Moore U, Porter B, Williams RJ. Bright C, et al. Among authors: lockey p. Bioorg Med Chem Lett. 1998 Apr 7;8(7):771-4. doi: 10.1016/s0960-894x(98)00094-8. Bioorg Med Chem Lett. 1998. PMID: 9871539

3

New low-density lipoprotein receptor upregulators acting via a novel mechanism.

Ashton MJ, Brown TJ, Fenton G, Halley F, Harper MF, Lockey PM, Porter B, Roach AG, Stuttle KA, Vicker N, Walsh RJ. Ashton MJ, et al. Among authors: lockey pm. J Med Chem. 1996 Aug 16;39(17):3343-56. doi: 10.1021/jm960153q. J Med Chem. 1996. PMID: 8765518

4

A virtual screening approach to finding novel and potent antagonists at the melanin-concentrating hormone 1 receptor.

Clark DE, Higgs C, Wren SP, Dyke HJ, Wong M, Norman D, Lockey PM, Roach AG. Clark DE, et al. Among authors: lockey pm. J Med Chem. 2004 Jul 29;47(16):3962-71. doi: 10.1021/jm040762v. J Med Chem. 2004. PMID: 15267235

5

Structure-activity relationships of a novel series of melanin-concentrating hormone (MCH) receptor antagonists.

Arienzo R, Clark DE, Cramp S, Daly S, Dyke HJ, Lockey P, Norman D, Roach AG, Stuttle K, Tomlinson M, Wong M, Wren SP. Arienzo R, et al. Among authors: lockey p. Bioorg Med Chem Lett. 2004 Aug 2;14(15):4099-102. doi: 10.1016/j.bmcl.2004.05.051. Bioorg Med Chem Lett. 2004. PMID: 15225734

6

Identification and optimisation of a series of substituted 5-(1H-pyrazol-3-yl)-thiophene-2-hydroxamic acids as potent histone deacetylase (HDAC) inhibitors.

Price S, Bordogna W, Bull RJ, Clark DE, Crackett PH, Dyke HJ, Gill M, Harris NV, Gorski J, Lloyd J, Lockey PM, Mullett J, Roach AG, Roussel F, White AB. Price S, et al. Bioorg Med Chem Lett. 2007 Jan 15;17(2):370-5. doi: 10.1016/j.bmcl.2006.10.048. Epub 2006 Oct 24. Bioorg Med Chem Lett. 2007. PMID: 17095213

7

Identification and optimisation of a series of substituted 5-pyridin-2-yl-thiophene-2-hydroxamic acids as potent histone deacetylase (HDAC) inhibitors.

Price S, Bordogna W, Braganza R, Bull RJ, Dyke HJ, Gardan S, Gill M, Harris NV, Heald RA, van den Heuvel M, Lockey PM, Lloyd J, Molina AG, Roach AG, Roussel F, Sutton JM, White AB. Price S, et al. Bioorg Med Chem Lett. 2007 Jan 15;17(2):363-9. doi: 10.1016/j.bmcl.2006.10.045. Epub 2006 Oct 24. Bioorg Med Chem Lett. 2007. PMID: 17107790

8

Quinazoline and benzimidazole MCH-1R antagonists.

Arienzo R, Cramp S, Dyke HJ, Lockey PM, Norman D, Roach AG, Smith P, Wong M, Wren SP. Arienzo R, et al. Among authors: lockey pm. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1403-7. doi: 10.1016/j.bmcl.2006.11.092. Epub 2006 Dec 2. Bioorg Med Chem Lett. 2007. PMID: 17178222

9

From virtual to clinical: The discovery of PGN-1531, a novel antagonist of the prostanoid EP4 receptor.

Sutton J, Clark DE, Higgs C, de Groot MJ, Harris NV, Taylor A, Lockey PM, Maubach K, Woodrooffe A, Davis RJ, Coleman RA, Clark KL. Sutton J, et al. Among authors: lockey pm. Bioorg Med Chem Lett. 2014 May 1;24(9):2212-21. doi: 10.1016/j.bmcl.2014.02.068. Epub 2014 Mar 12. Bioorg Med Chem Lett. 2014. PMID: 24703233

10

Discovery and optimization of novel, non-steroidal glucocorticoid receptor modulators.

Ray NC, Clark RD, Clark DE, Williams K, Hickin HG, Crackett PH, Dyke HJ, Lockey PM, Wong M, Devos R, White A, Belanoff JK. Ray NC, et al. Bioorg Med Chem Lett. 2007 Sep 1;17(17):4901-5. doi: 10.1016/j.bmcl.2007.06.036. Epub 2007 Jun 13. Bioorg Med Chem Lett. 2007. PMID: 17587578

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