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Recombinant modified vaccinia virus Ankara-simian immunodeficiency virus gag pol elicits cytotoxic T lymphocytes in rhesus monkeys detected by a major histocompatibility complex class I/peptide tetramer.
Seth A, Ourmanov I, Kuroda MJ, Schmitz JE, Carroll MW, Wyatt LS, Moss B, Forman MA, Hirsch VM, Letvin NL. Seth A, et al. Among authors: ourmanov i. Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):10112-6. doi: 10.1073/pnas.95.17.10112. Proc Natl Acad Sci U S A. 1998. PMID: 9707609 Free PMC article.
Immunization with a modified vaccinia virus expressing simian immunodeficiency virus (SIV) Gag-Pol primes for an anamnestic Gag-specific cytotoxic T-lymphocyte response and is associated with reduction of viremia after SIV challenge.
Seth A, Ourmanov I, Schmitz JE, Kuroda MJ, Lifton MA, Nickerson CE, Wyatt L, Carroll M, Moss B, Venzon D, Letvin NL, Hirsch VM. Seth A, et al. Among authors: ourmanov i. J Virol. 2000 Mar;74(6):2502-9. doi: 10.1128/jvi.74.6.2502-2509.2000. J Virol. 2000. PMID: 10684264 Free PMC article.
Recombinant modified vaccinia virus ankara expressing the surface gp120 of simian immunodeficiency virus (SIV) primes for a rapid neutralizing antibody response to SIV infection in macaques.
Ourmanov I, Bilska M, Hirsch VM, Montefiori DC. Ourmanov I, et al. J Virol. 2000 Mar;74(6):2960-5. doi: 10.1128/jvi.74.6.2960-2965.2000. J Virol. 2000. PMID: 10684319 Free PMC article.
Although no animals were completely protected from infection with SIV, animals immunized with recombinant MVA-SIV vaccines had lower virus loads and prolonged survival relative to control animals that received nonrecombinant MVA (I. Ourmanov et al., J. Virol. 74:274 …
Although no animals were completely protected from infection with SIV, animals immunized with recombinant MVA-SIV vaccines had lower virus l …
Vaccine protection against acquisition of neutralization-resistant SIV challenges in rhesus monkeys.
Barouch DH, Liu J, Li H, Maxfield LF, Abbink P, Lynch DM, Iampietro MJ, SanMiguel A, Seaman MS, Ferrari G, Forthal DN, Ourmanov I, Hirsch VM, Carville A, Mansfield KG, Stablein D, Pau MG, Schuitemaker H, Sadoff JC, Billings EA, Rao M, Robb ML, Kim JH, Marovich MA, Goudsmit J, Michael NL. Barouch DH, et al. Among authors: ourmanov i. Nature. 2012 Jan 4;482(7383):89-93. doi: 10.1038/nature10766. Nature. 2012. PMID: 22217938 Free PMC article.
Immune failure in the absence of profound CD4+ T-lymphocyte depletion in simian immunodeficiency virus-infected rapid progressor macaques.
Hirsch VM, Santra S, Goldstein S, Plishka R, Buckler-White A, Seth A, Ourmanov I, Brown CR, Engle R, Montefiori D, Glowczwskie J, Kunstman K, Wolinsky S, Letvin NL. Hirsch VM, et al. Among authors: ourmanov i. J Virol. 2004 Jan;78(1):275-84. doi: 10.1128/jvi.78.1.275-284.2004. J Virol. 2004. PMID: 14671109 Free PMC article.
Improved survival in rhesus macaques immunized with modified vaccinia virus Ankara recombinants expressing simian immunodeficiency virus envelope correlates with reduction in memory CD4+ T-cell loss and higher titers of neutralizing antibody.
Ourmanov I, Kuwata T, Goeken R, Goldstein S, Iyengar R, Buckler-White A, Lafont B, Hirsch VM. Ourmanov I, et al. J Virol. 2009 Jun;83(11):5388-400. doi: 10.1128/JVI.02598-08. Epub 2009 Mar 25. J Virol. 2009. PMID: 19321617 Free PMC article.
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