Freidinger RM - Search Results

1

Synthesis and biological activities of potent peptidomimetics selective for somatostatin receptor subtype 2.

Yang L, Berk SC, Rohrer SP, Mosley RT, Guo L, Underwood DJ, Arison BH, Birzin ET, Hayes EC, Mitra SW, Parmar RM, Cheng K, Wu TJ, Butler BS, Foor F, Pasternak A, Pan Y, Silva M, Freidinger RM, Smith RG, Chapman K, Schaeffer JM, Patchett AA. Yang L, et al. Among authors: freidinger rm. Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10836-41. doi: 10.1073/pnas.95.18.10836. Proc Natl Acad Sci U S A. 1998. PMID: 9724791 Free PMC article.

2

Conformational modifications of cyclic hexapeptide somatostatin analogs.

Freidinger RM, Perlow DS, Randall WC, Saperstein R, Arison BH, Veber DF. Freidinger RM, et al. Int J Pept Protein Res. 1984 Feb;23(2):142-50. doi: 10.1111/j.1399-3011.1984.tb02704.x. Int J Pept Protein Res. 1984. PMID: 6142021

3

Chemical synthesis of echistatin, a potent inhibitor of platelet aggregation from Echis carinatus: synthesis and biological activity of selected analogs.

Garsky VM, Lumma PK, Freidinger RM, Pitzenberger SM, Randall WC, Veber DF, Gould RJ, Friedman PA. Garsky VM, et al. Among authors: freidinger rm. Proc Natl Acad Sci U S A. 1989 Jun;86(11):4022-6. doi: 10.1073/pnas.86.11.4022. Proc Natl Acad Sci U S A. 1989. PMID: 2726764 Free PMC article.

4

Benzodiazepines as potent and selective bradykinin B1 antagonists.

Wood MR, Kim JJ, Han W, Dorsey BD, Homnick CF, DiPardo RM, Kuduk SD, MacNeil T, Murphy KL, Lis EV, Ransom RW, Stump GL, Lynch JJ, O'Malley SS, Miller PJ, Chen TB, Harrell CM, Chang RS, Sandhu P, Ellis JD, Bondiskey PJ, Pettibone DJ, Freidinger RM, Bock MG. Wood MR, et al. Among authors: freidinger rm. J Med Chem. 2003 May 8;46(10):1803-6. doi: 10.1021/jm034020y. J Med Chem. 2003. PMID: 12723943

5

A nonpeptide oxytocin receptor antagonist radioligand highly selective for human receptors.

Lemaire W, O'Brien JA, Burno M, Chaudhary AG, Dean DC, Williams PD, Freidinger RM, Pettibone DJ, Williams DL Jr. Lemaire W, et al. Among authors: freidinger rm. Eur J Pharmacol. 2002 Aug 16;450(1):19-28. doi: 10.1016/s0014-2999(02)02048-4. Eur J Pharmacol. 2002. PMID: 12176104

6

Identification of a series of CCK-2 receptor nonpeptide agonists: sensitivity to stereochemistry and a receptor point mutation.

Kopin AS, McBride EW, Chen C, Freidinger RM, Chen D, Zhao CM, Beinborn M. Kopin AS, et al. Among authors: freidinger rm. Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5525-30. doi: 10.1073/pnas.0831223100. Epub 2003 Apr 15. Proc Natl Acad Sci U S A. 2003. PMID: 12697901 Free PMC article.

7

Design and synthesis of novel bioactive peptides and peptidomimetics.

Freidinger RM. Freidinger RM. J Med Chem. 2003 Dec 18;46(26):5553-66. doi: 10.1021/jm030484k. J Med Chem. 2003. PMID: 14667208 No abstract available.

8

In vitro and in vivo evaluation of dihydropyrimidinone C-5 amides as potent and selective alpha(1A) receptor antagonists for the treatment of benign prostatic hyperplasia.

Barrow JC, Nantermet PG, Selnick HG, Glass KL, Rittle KE, Gilbert KF, Steele TG, Homnick CF, Freidinger RM, Ransom RW, Kling P, Reiss D, Broten TP, Schorn TW, Chang RS, O'Malley SS, Olah TV, Ellis JD, Barrish A, Kassahun K, Leppert P, Nagarathnam D, Forray C. Barrow JC, et al. Among authors: freidinger rm. J Med Chem. 2000 Jul 13;43(14):2703-18. doi: 10.1021/jm990612y. J Med Chem. 2000. PMID: 10893308

9

Preparation and evaluation of 1,3-diaminocyclopentane-linked dihydropyrimidinone derivatives as selective alpha1a-receptor antagonists.

Barrow JC, Glass KL, Selnick HG, Freidinger RM, Chang RS, O'Malley SS, Woyden C. Barrow JC, et al. Among authors: freidinger rm. Bioorg Med Chem Lett. 2000 Sep 4;10(17):1917-20. doi: 10.1016/s0960-894x(00)00374-7. Bioorg Med Chem Lett. 2000. PMID: 10987417

10

NR2B-selective N-methyl-D-aspartate antagonists: synthesis and evaluation of 5-substituted benzimidazoles.

McCauley JA, Theberge CR, Romano JJ, Billings SB, Anderson KD, Claremon DA, Freidinger RM, Bednar RA, Mosser SD, Gaul SL, Connolly TM, Condra CL, Xia M, Cunningham ME, Bednar B, Stump GL, Lynch JJ, Macaulay A, Wafford KA, Koblan KS, Liverton NJ. McCauley JA, et al. Among authors: freidinger rm. J Med Chem. 2004 Apr 8;47(8):2089-96. doi: 10.1021/jm030483s. J Med Chem. 2004. PMID: 15056006

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