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Distinct mechanism for antidepressant activity by blockade of central substance P receptors.
Kramer MS, Cutler N, Feighner J, Shrivastava R, Carman J, Sramek JJ, Reines SA, Liu G, Snavely D, Wyatt-Knowles E, Hale JJ, Mills SG, MacCoss M, Swain CJ, Harrison T, Hill RG, Hefti F, Scolnick EM, Cascieri MA, Chicchi GG, Sadowski S, Williams AR, Hewson L, Smith D, Carlson EJ, Hargreaves RJ, Rupniak NM. Kramer MS, et al. Among authors: reines sa. Science. 1998 Sep 11;281(5383):1640-5. doi: 10.1126/science.281.5383.1640. Science. 1998. PMID: 9733503 Clinical Trial.
Demonstration of the efficacy and safety of a novel substance P (NK1) receptor antagonist in major depression.
Kramer MS, Winokur A, Kelsey J, Preskorn SH, Rothschild AJ, Snavely D, Ghosh K, Ball WA, Reines SA, Munjack D, Apter JT, Cunningham L, Kling M, Bari M, Getson A, Lee Y. Kramer MS, et al. Among authors: reines sa. Neuropsychopharmacology. 2004 Feb;29(2):385-92. doi: 10.1038/sj.npp.1300260. Neuropsychopharmacology. 2004. PMID: 14666114 Clinical Trial.
Is bigger better for depression trials?
Liu KS, Snavely DB, Ball WA, Lines CR, Reines SA, Potter WZ. Liu KS, et al. Among authors: reines sa. J Psychiatr Res. 2008 Jul;42(8):622-30. doi: 10.1016/j.jpsychires.2007.07.003. Epub 2007 Sep 7. J Psychiatr Res. 2008. PMID: 17825841
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