Swain CJ - Search Results

1

Distinct mechanism for antidepressant activity by blockade of central substance P receptors.

Kramer MS, Cutler N, Feighner J, Shrivastava R, Carman J, Sramek JJ, Reines SA, Liu G, Snavely D, Wyatt-Knowles E, Hale JJ, Mills SG, MacCoss M, Swain CJ, Harrison T, Hill RG, Hefti F, Scolnick EM, Cascieri MA, Chicchi GG, Sadowski S, Williams AR, Hewson L, Smith D, Carlson EJ, Hargreaves RJ, Rupniak NM. Kramer MS, et al. Among authors: swain cj. Science. 1998 Sep 11;281(5383):1640-5. doi: 10.1126/science.281.5383.1640. Science. 1998. PMID: 9733503 Clinical Trial.

2

Comparison of the functional blockade of rat substance P (NK1) receptors by GR205171, RP67580, SR140333 and NKP-608.

Rupniak NM, Carlson EJ, Shepheard S, Bentley G, Williams AR, Hill A, Swain C, Mills SG, Di Salvo J, Kilburn R, Cascieri MA, Kurtz MM, Tsao KL, Gould SL, Chicchi GG. Rupniak NM, et al. Neuropharmacology. 2003 Aug;45(2):231-41. doi: 10.1016/s0028-3908(03)00157-6. Neuropharmacology. 2003. PMID: 12842129

3

Characterization of the interaction of diacylpiperazine antagonists with the human neurokinin-1 receptor: identification of a common binding site for structurally dissimilar antagonists.

Cascieri MA, Shiao LL, Mills SG, MacCoss M, Swain CJ, Yu H, Ber E, Sadowski S, Wu MT, Strader CD, et al. Cascieri MA, et al. Among authors: swain cj. Mol Pharmacol. 1995 Apr;47(4):660-5. Mol Pharmacol. 1995. PMID: 7536886

4

In vitro and in vivo predictors of the anti-emetic activity of tachykinin NK1 receptor antagonists.

Rupniak NM, Tattersall FD, Williams AR, Rycroft W, Carlson EJ, Cascieri MA, Sadowski S, Ber E, Hale JJ, Mills SG, MacCoss M, Seward E, Huscroft I, Owen S, Swain CJ, Hill RG, Hargreaves RJ. Rupniak NM, et al. Among authors: swain cj. Eur J Pharmacol. 1997 May 20;326(2-3):201-9. doi: 10.1016/s0014-2999(97)85415-5. Eur J Pharmacol. 1997. PMID: 9196273

5

An orally active, water-soluble neurokinin-1 receptor antagonist suitable for both intravenous and oral clinical administration.

Harrison T, Owens AP, Williams BJ, Swain CJ, Williams A, Carlson EJ, Rycroft W, Tattersall FD, Cascieri MA, Chicchi GG, Sadowski S, Rupniak NM, Hargreaves RJ. Harrison T, et al. Among authors: swain cj. J Med Chem. 2001 Nov 22;44(24):4296-9. doi: 10.1021/jm0109558. J Med Chem. 2001. PMID: 11708932

6

Chronic substance P (NK1) receptor antagonist and conventional antidepressant treatment increases burst firing of monoamine neurones in the locus coeruleus.

Maubach KA, Martin K, Chicchi G, Harrison T, Wheeldon A, Swain CJ, Cumberbatch MJ, Rupniak NM, Seabrook GR. Maubach KA, et al. Among authors: swain cj. Neuroscience. 2002;109(3):609-17. doi: 10.1016/s0306-4522(01)00467-5. Neuroscience. 2002. PMID: 11823070

7

Substance P (neurokinin 1) receptor antagonists enhance dorsal raphe neuronal activity.

Conley RK, Cumberbatch MJ, Mason GS, Williamson DJ, Harrison T, Locker K, Swain C, Maubach K, O'Donnell R, Rigby M, Hewson L, Smith D, Rupniak NM. Conley RK, et al. J Neurosci. 2002 Sep 1;22(17):7730-6. doi: 10.1523/JNEUROSCI.22-17-07730.2002. J Neurosci. 2002. PMID: 12196596 Free PMC article.

8

Spirocyclic NK(1) antagonists II: [4.5]-spiroethers.

Williams BJ, Cascieri MA, Chicchi GG, Harrison T, Owens AP, Owen SN, Rupniak NM, Tattersall DF, Williams A, Swain CJ. Williams BJ, et al. Among authors: swain cj. Bioorg Med Chem Lett. 2002 Oct 7;12(19):2719-22. doi: 10.1016/s0960-894x(02)00509-7. Bioorg Med Chem Lett. 2002. PMID: 12217362

9

N-acyl-L-tryptophan benzyl esters: potent substance P receptor antagonists.

MacLeod AM, Merchant KJ, Cascieri MA, Sadowski S, Ber E, Swain CJ, Baker R. MacLeod AM, et al. Among authors: swain cj. J Med Chem. 1993 Jul 9;36(14):2044-5. doi: 10.1021/jm00066a015. J Med Chem. 1993. PMID: 8393115 No abstract available.

10

Mutational analysis of neurokinin receptor function.

Fong TM, Huang RC, Yu H, Swain CJ, Underwood D, Cascieri MA, Strader CD. Fong TM, et al. Among authors: swain cj. Can J Physiol Pharmacol. 1995 Jul;73(7):860-5. doi: 10.1139/y95-118. Can J Physiol Pharmacol. 1995. PMID: 8846422 Review.

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