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Phase I study of direct administration of a replication deficient adenovirus vector containing the E. coli cytosine deaminase gene to metastatic colon carcinoma of the liver in association with the oral administration of the pro-drug 5-fluorocytosine.
Crystal RG, Hirschowitz E, Lieberman M, Daly J, Kazam E, Henschke C, Yankelevitz D, Kemeny N, Silverstein R, Ohwada A, Russi T, Mastrangeli A, Sanders A, Cooke J, Harvey BG. Crystal RG, et al. Hum Gene Ther. 1997 May 20;8(8):985-1001. doi: 10.1089/hum.1997.8.8-985. Hum Gene Ther. 1997. PMID: 9195221 Clinical Trial. No abstract available.
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