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A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis.
Thornberry NA, Rano TA, Peterson EP, Rasper DM, Timkey T, Garcia-Calvo M, Houtzager VM, Nordstrom PA, Roy S, Vaillancourt JP, Chapman KT, Nicholson DW. Thornberry NA, et al. Among authors: nicholson dw. J Biol Chem. 1997 Jul 18;272(29):17907-11. doi: 10.1074/jbc.272.29.17907. J Biol Chem. 1997. PMID: 9218414 Free article.
Purification and catalytic properties of human caspase family members.
Garcia-Calvo M, Peterson EP, Rasper DM, Vaillancourt JP, Zamboni R, Nicholson DW, Thornberry NA. Garcia-Calvo M, et al. Among authors: nicholson dw. Cell Death Differ. 1999 Apr;6(4):362-9. doi: 10.1038/sj.cdd.4400497. Cell Death Differ. 1999. PMID: 10381624
Reducing the peptidyl features of caspase-3 inhibitors: a structural analysis.
Becker JW, Rotonda J, Soisson SM, Aspiotis R, Bayly C, Francoeur S, Gallant M, Garcia-Calvo M, Giroux A, Grimm E, Han Y, McKay D, Nicholson DW, Peterson E, Renaud J, Roy S, Thornberry N, Zamboni R. Becker JW, et al. Among authors: nicholson dw. J Med Chem. 2004 May 6;47(10):2466-74. doi: 10.1021/jm0305523. J Med Chem. 2004. PMID: 15115390
The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis.
Rotonda J, Nicholson DW, Fazil KM, Gallant M, Gareau Y, Labelle M, Peterson EP, Rasper DM, Ruel R, Vaillancourt JP, Thornberry NA, Becker JW. Rotonda J, et al. Among authors: nicholson dw. Nat Struct Biol. 1996 Jul;3(7):619-25. doi: 10.1038/nsb0796-619. Nat Struct Biol. 1996. PMID: 8673606
Caspases: killer proteases.
Nicholson DW, Thornberry NA. Nicholson DW, et al. Trends Biochem Sci. 1997 Aug;22(8):299-306. doi: 10.1016/s0968-0004(97)01085-2. Trends Biochem Sci. 1997. PMID: 9270303 Review.
Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation.
Gervais FG, Xu D, Robertson GS, Vaillancourt JP, Zhu Y, Huang J, LeBlanc A, Smith D, Rigby M, Shearman MS, Clarke EE, Zheng H, Van Der Ploeg LH, Ruffolo SC, Thornberry NA, Xanthoudakis S, Zamboni RJ, Roy S, Nicholson DW. Gervais FG, et al. Among authors: nicholson dw. Cell. 1999 Apr 30;97(3):395-406. doi: 10.1016/s0092-8674(00)80748-5. Cell. 1999. PMID: 10319819 Free article.
162 results