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Page 1
N-carbamoyl analogs of Zafirlukast: potent receptor antagonists of leukotriene D4.
Brown MF, Marfat A, Antognoli G, Chambers RJ, Cheng JB, Damon DB, Liston TE, McGlynn MA, O'Sullivan SP, Owens BS, Pillar JS, Shirley JT, Watson JW. Brown MF, et al. Among authors: marfat a. Bioorg Med Chem Lett. 1998 Sep 22;8(18):2451-6. doi: 10.1016/s0960-894x(98)00442-9. Bioorg Med Chem Lett. 1998. PMID: 9873560
Biarylcarboxylic acids and -amides: inhibition of phosphodiesterase type IV versus [3H]rolipram binding activity and their relationship to emetic behavior in the ferret.
Duplantier AJ, Biggers MS, Chambers RJ, Cheng JB, Cooper K, Damon DB, Eggler JF, Kraus KG, Marfat A, Masamune H, Pillar JS, Shirley JT, Umland JP, Watson JW. Duplantier AJ, et al. Among authors: marfat a. J Med Chem. 1996 Jan 5;39(1):120-5. doi: 10.1021/jm9505066. J Med Chem. 1996. PMID: 8568798
Development of new chromanol antagonists of leukotriene D4.
Chambers RJ, Antognoli GW, Cheng JB, Marfat A, Pillar JS, Shirley JT, Watson JW. Chambers RJ, et al. Among authors: marfat a. Bioorg Med Chem Lett. 1998 Jul 21;8(14):1791-6. doi: 10.1016/s0960-894x(98)00273-x. Bioorg Med Chem Lett. 1998. PMID: 9873435
Development of 2,2-dimethylchromanol cysteinyl LT1 receptor antagonists.
Chambers RJ, Antognoli GW, Cheng JB, Kuperman AV, Liston TC, Marfat A, Owens BS, Pillar JS, Shirley JT, Watson JW. Chambers RJ, et al. Among authors: marfat a. Bioorg Med Chem Lett. 1998 Dec 15;8(24):3577-82. doi: 10.1016/s0960-894x(98)00654-4. Bioorg Med Chem Lett. 1998. PMID: 9934474
A new chemical tool for exploring the role of the PDE4D isozyme in leukocyte function.
Chambers RJ, Abrams K, Castleberry TA, Cheng JB, Fisher DA, Kamath AV, Marfat A, Nettleton DO, Pillar JD, Salter ED, Sheils AL, Shirley JT, Turner CR, Umland JP, Lam KT. Chambers RJ, et al. Among authors: marfat a. Bioorg Med Chem Lett. 2006 Feb;16(3):718-21. doi: 10.1016/j.bmcl.2005.10.026. Epub 2005 Nov 2. Bioorg Med Chem Lett. 2006. PMID: 16263279
The identification of orally bioavailable thrombopoietin agonists.
Munchhof MJ, Antipas AS, Blumberg LC, Brissette WH, Brown MF, Casavant JM, Doty JL, Driscoll J, Harris TM, Wolf-Gouveia LA, Jones CS, Li Q, Linde RG, Lira PD, Marfat A, McElroy E, Mitton-Fry M, McCurdy SP, Reiter LA, Ripp SL, Shavnya A, Thomasco LM, Trevena KA. Munchhof MJ, et al. Among authors: marfat a. Bioorg Med Chem Lett. 2009 Mar 1;19(5):1428-30. doi: 10.1016/j.bmcl.2009.01.032. Epub 2009 Jan 15. Bioorg Med Chem Lett. 2009. PMID: 19186055
Potent inhibitors of LpxC for the treatment of Gram-negative infections.
Brown MF, Reilly U, Abramite JA, Arcari JT, Oliver R, Barham RA, Che Y, Chen JM, Collantes EM, Chung SW, Desbonnet C, Doty J, Doroski M, Engtrakul JJ, Harris TM, Huband M, Knafels JD, Leach KL, Liu S, Marfat A, Marra A, McElroy E, Melnick M, Menard CA, Montgomery JI, Mullins L, Noe MC, O'Donnell J, Penzien J, Plummer MS, Price LM, Shanmugasundaram V, Thoma C, Uccello DP, Warmus JS, Wishka DG. Brown MF, et al. Among authors: marfat a. J Med Chem. 2012 Jan 26;55(2):914-23. doi: 10.1021/jm2014748. Epub 2012 Jan 11. J Med Chem. 2012. PMID: 22175825
Pyridone methylsulfone hydroxamate LpxC inhibitors for the treatment of serious gram-negative infections.
Montgomery JI, Brown MF, Reilly U, Price LM, Abramite JA, Arcari J, Barham R, Che Y, Chen JM, Chung SW, Collantes EM, Desbonnet C, Doroski M, Doty J, Engtrakul JJ, Harris TM, Huband M, Knafels JD, Leach KL, Liu S, Marfat A, McAllister L, McElroy E, Menard CA, Mitton-Fry M, Mullins L, Noe MC, O'Donnell J, Oliver R, Penzien J, Plummer M, Shanmugasundaram V, Thoma C, Tomaras AP, Uccello DP, Vaz A, Wishka DG. Montgomery JI, et al. Among authors: marfat a. J Med Chem. 2012 Feb 23;55(4):1662-70. doi: 10.1021/jm2014875. Epub 2012 Feb 8. J Med Chem. 2012. PMID: 22257165
29 results