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The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus.
Nature. 1999 Jan 14;397(6715):164-8. doi: 10.1038/16476.
Nature. 1999.
PMID: 9923679
Ink4a and Arf differentially affect cell proliferation and neural stem cell self-renewal in Bmi1-deficient mice.
Bruggeman SW, Valk-Lingbeek ME, van der Stoop PP, Jacobs JJ, Kieboom K, Tanger E, Hulsman D, Leung C, Arsenijevic Y, Marino S, van Lohuizen M.
Bruggeman SW, et al. Among authors: kieboom k.
Genes Dev. 2005 Jun 15;19(12):1438-43. doi: 10.1101/gad.1299305.
Genes Dev. 2005.
PMID: 15964995
Free PMC article.
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Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF.
Jacobs JJ, Scheijen B, Voncken JW, Kieboom K, Berns A, van Lohuizen M.
Jacobs JJ, et al. Among authors: kieboom k.
Genes Dev. 1999 Oct 15;13(20):2678-90. doi: 10.1101/gad.13.20.2678.
Genes Dev. 1999.
PMID: 10541554
Free PMC article.
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Genetic interactions and dosage effects of Polycomb group genes in mice.
Bel S, Coré N, Djabali M, Kieboom K, Van der Lugt N, Alkema MJ, Van Lohuizen M.
Bel S, et al. Among authors: kieboom k.
Development. 1998 Sep;125(18):3543-51. doi: 10.1242/dev.125.18.3543.
Development. 1998.
PMID: 9716520
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