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Steroid biomarkers and genetic studies reveal inactivating mutations in hexose-6-phosphate dehydrogenase in patients with cortisone reductase deficiency.
Lavery GG, Walker EA, Tiganescu A, Ride JP, Shackleton CH, Tomlinson JW, Connell JM, Ray DW, Biason-Lauber A, Malunowicz EM, Arlt W, Stewart PM. Lavery GG, et al. J Clin Endocrinol Metab. 2008 Oct;93(10):3827-32. doi: 10.1210/jc.2008-0743. Epub 2008 Jul 15. J Clin Endocrinol Metab. 2008. PMID: 18628520 Free PMC article.
Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 activity in vivo limits glucocorticoid exposure to human adipose tissue and decreases lipolysis.
Tomlinson JW, Sherlock M, Hughes B, Hughes SV, Kilvington F, Bartlett W, Courtney R, Rejto P, Carley W, Stewart PM. Tomlinson JW, et al. J Clin Endocrinol Metab. 2007 Mar;92(3):857-64. doi: 10.1210/jc.2006-2325. Epub 2007 Jan 2. J Clin Endocrinol Metab. 2007. PMID: 17200165 Free PMC article. Clinical Trial.