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The CD46-Jagged1 interaction is critical for human TH1 immunity.
Le Friec G, Sheppard D, Whiteman P, Karsten CM, Shamoun SA, Laing A, Bugeon L, Dallman MJ, Melchionna T, Chillakuri C, Smith RA, Drouet C, Couzi L, Fremeaux-Bacchi V, Köhl J, Waddington SN, McDonnell JM, Baker A, Handford PA, Lea SM, Kemper C. Le Friec G, et al. Nat Immunol. 2012 Dec;13(12):1213-21. doi: 10.1038/ni.2454. Epub 2012 Oct 21. Nat Immunol. 2012. PMID: 23086448 Free PMC article.
Structural analysis uncovers lipid-binding properties of Notch ligands.
Chillakuri CR, Sheppard D, Ilagan MX, Holt LR, Abbott F, Liang S, Kopan R, Handford PA, Lea SM. Chillakuri CR, et al. Cell Rep. 2013 Nov 27;5(4):861-7. doi: 10.1016/j.celrep.2013.10.029. Epub 2013 Nov 14. Cell Rep. 2013. PMID: 24239355 Free PMC article.