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Highly Potent and Isoform Selective Dual Site Binding Tankyrase/Wnt Signaling Inhibitors That Increase Cellular Glucose Uptake and Have Antiproliferative Activity.
J Med Chem. 2017 Jan 26;60(2):814-820. doi: 10.1021/acs.jmedchem.6b01574. Epub 2017 Jan 9.
J Med Chem. 2017.
PMID: 27983846
Free article.
Structure-based design, synthesis and evaluation in vitro of arylnaphthyridinones, arylpyridopyrimidinones and their tetrahydro derivatives as inhibitors of the tankyrases.
Kumpan K, Nathubhai A, Zhang C, Wood PJ, Lloyd MD, Thompson AS, Haikarainen T, Lehtiö L, Threadgill MD.
Kumpan K, et al.
Bioorg Med Chem. 2015 Jul 1;23(13):3013-32. doi: 10.1016/j.bmc.2015.05.005. Epub 2015 May 13.
Bioorg Med Chem. 2015.
PMID: 26026769
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Structure-activity relationships of 2-arylquinazolin-4-ones as highly selective and potent inhibitors of the tankyrases.
Nathubhai A, Haikarainen T, Hayward PC, Muñoz-Descalzo S, Thompson AS, Lloyd MD, Lehtiö L, Threadgill MD.
Nathubhai A, et al.
Eur J Med Chem. 2016 Aug 8;118:316-27. doi: 10.1016/j.ejmech.2016.04.041. Epub 2016 Apr 20.
Eur J Med Chem. 2016.
PMID: 27163581
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