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Page 1
RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS.
Ito Y, Ofengeim D, Najafov A, Das S, Saberi S, Li Y, Hitomi J, Zhu H, Chen H, Mayo L, Geng J, Amin P, DeWitt JP, Mookhtiar AK, Florez M, Ouchida AT, Fan JB, Pasparakis M, Kelliher MA, Ravits J, Yuan J. Ito Y, et al. Science. 2016 Aug 5;353(6299):603-8. doi: 10.1126/science.aaf6803. Science. 2016. PMID: 27493188 Free PMC article.
Necroptosis in health and diseases.
Zhou W, Yuan J. Zhou W, et al. Semin Cell Dev Biol. 2014 Nov;35:14-23. doi: 10.1016/j.semcdb.2014.07.013. Epub 2014 Aug 1. Semin Cell Dev Biol. 2014. PMID: 25087983 Free article. Review.
Pharmacologic agents targeting autophagy.
Vakifahmetoglu-Norberg H, Xia HG, Yuan J. Vakifahmetoglu-Norberg H, et al. J Clin Invest. 2015 Jan;125(1):5-13. doi: 10.1172/JCI73937. Epub 2015 Jan 2. J Clin Invest. 2015. PMID: 25654545 Free PMC article. Review.
Assays for necroptosis and activity of RIP kinases.
Degterev A, Zhou W, Maki JL, Yuan J. Degterev A, et al. Methods Enzymol. 2014;545:1-33. doi: 10.1016/B978-0-12-801430-1.00001-9. Methods Enzymol. 2014. PMID: 25065884 Review.
Activation of necroptosis in multiple sclerosis.
Ofengeim D, Ito Y, Najafov A, Zhang Y, Shan B, DeWitt JP, Ye J, Zhang X, Chang A, Vakifahmetoglu-Norberg H, Geng J, Py B, Zhou W, Amin P, Berlink Lima J, Qi C, Yu Q, Trapp B, Yuan J. Ofengeim D, et al. Cell Rep. 2015 Mar 24;10(11):1836-49. doi: 10.1016/j.celrep.2015.02.051. Cell Rep. 2015. PMID: 25801023 Free PMC article.