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Cell-permeable pentapeptide V5 inhibits apoptosis and enhances insulin secretion, allowing experimental single-donor islet transplantation in mice.
Rivas-Carrillo JD, Soto-Gutierrez A, Navarro-Alvarez N, Noguchi H, Okitsu T, Chen Y, Yuasa T, Tanaka K, Narushima M, Miki A, Misawa H, Tabata Y, Jun HS, Matsumoto S, Fox IJ, Tanaka N, Kobayashi N. Rivas-Carrillo JD, et al. Diabetes. 2007 May;56(5):1259-67. doi: 10.2337/db06-1679. Epub 2007 Feb 7. Diabetes. 2007. PMID: 17287463
A human beta-cell line for transplantation therapy to control type 1 diabetes.
Narushima M, Kobayashi N, Okitsu T, Tanaka Y, Li SA, Chen Y, Miki A, Tanaka K, Nakaji S, Takei K, Gutierrez AS, Rivas-Carrillo JD, Navarro-Alvarez N, Jun HS, Westerman KA, Noguchi H, Lakey JR, Leboulch P, Tanaka N, Yoon JW. Narushima M, et al. Nat Biotechnol. 2005 Oct;23(10):1274-82. doi: 10.1038/nbt1145. Epub 2005 Sep 25. Nat Biotechnol. 2005. PMID: 16186810