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Synthesis and evaluation of an anti-MLC1 × anti-CD90 bispecific antibody for targeting and retaining bone-marrow-derived multipotent stromal cells in infarcted myocardium.
Gundlach CW 4th, Caivano A, Cabreira-Hansen Mda G, Gahremanpour A, Brown WS, Zheng Y, McIntyre BW, Willerson JT, Dixon RA, Perin EC, Woodside DG. Gundlach CW 4th, et al. Bioconjug Chem. 2011 Aug 17;22(8):1706-14. doi: 10.1021/bc200309h. Epub 2011 Aug 2. Bioconjug Chem. 2011. PMID: 21749133 Free PMC article.
We modified the anti-CD90 antibody with a pegylated-4-formylbenzamide moiety to a molar substitution ratio (MSR) of 2.6 and the anti-MLC1 antibody with a 6-hydrazinonicotinamide moiety to a MSR of 0.9. ...
We modified the anti-CD90 antibody with a pegylated-4-formylbenzamide moiety to a molar substitution ratio (MSR) of 2.6 and the anti- …