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Anti-Tumor Activity and Mechanism of Silibinin Based on Network Pharmacology and Experimental Verification.
Li P, Wang D, Yang X, Liu C, Li X, Zhang X, Liu K, Zhang Y, Zhang M, Wang C, Wang R. Li P, et al. Molecules. 2024 Apr 22;29(8):1901. doi: 10.3390/molecules29081901. Molecules. 2024. PMID: 38675723 Free PMC article.
Based on the PPI analysis, CASP3, SRC, ESR1, JAK2, PRKACA, HSPA8 and CAT showed stronger interactions with other factors and may be the key targets of silibinin for treating tumors. The predicted target proteins according to network pharmacology were verified using Western …
Based on the PPI analysis, CASP3, SRC, ESR1, JAK2, PRKACA, HSPA8 and CAT showed stronger interactions with other factors and may be the k …