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Page 1
A blood atlas of COVID-19 defines hallmarks of disease severity and specificity.
COvid-19 Multi-omics Blood ATlas (COMBAT) Consortium. Electronic address: julian.knight@well.ox.ac.uk; COvid-19 Multi-omics Blood ATlas (COMBAT) Consortium. COvid-19 Multi-omics Blood ATlas (COMBAT) Consortium. Electronic address: julian.knight@well.ox.ac.uk, et al. Cell. 2022 Mar 3;185(5):916-938.e58. doi: 10.1016/j.cell.2022.01.012. Epub 2022 Jan 21. Cell. 2022. PMID: 35216673 Free PMC article.
Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders.
Eijsbouts C, Zheng T, Kennedy NA, Bonfiglio F, Anderson CA, Moutsianas L, Holliday J, Shi J, Shringarpure S; 23andMe Research Team; Voda AI; Bellygenes Initiative; Farrugia G, Franke A, Hübenthal M, Abecasis G, Zawistowski M, Skogholt AH, Ness-Jensen E, Hveem K, Esko T, Teder-Laving M, Zhernakova A, Camilleri M, Boeckxstaens G, Whorwell PJ, Spiller R, McVean G, D'Amato M, Jostins L, Parkes M. Eijsbouts C, et al. Nat Genet. 2021 Nov;53(11):1543-1552. doi: 10.1038/s41588-021-00950-8. Epub 2021 Nov 5. Nat Genet. 2021. PMID: 34741163 Free PMC article.
Lifetime risk and genetic predisposition to post-traumatic OA of the knee in the UK Biobank.
Hollis B, Chatzigeorgiou C, Southam L, Hatzikotoulas K, Kluzek S, Williams A; Genetics of Osteoarthritis Consortium; Zeggini E, Jostins-Dean L, Watt FE. Hollis B, et al. Osteoarthritis Cartilage. 2023 Oct;31(10):1377-1387. doi: 10.1016/j.joca.2023.05.012. Epub 2023 May 27. Osteoarthritis Cartilage. 2023. PMID: 37247657 Free article.
Defactinib inhibits PYK2 phosphorylation of IRF5 and reduces intestinal inflammation.
Ryzhakov G, Almuttaqi H, Corbin AL, Berthold DL, Khoyratty T, Eames HL, Bullers S, Pearson C, Ai Z, Zec K, Bonham S, Fischer R, Jostins-Dean L, Travis SPL, Kessler BM, Udalova IA. Ryzhakov G, et al. Nat Commun. 2021 Nov 18;12(1):6702. doi: 10.1038/s41467-021-27038-5. Nat Commun. 2021. PMID: 34795257 Free PMC article.