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A rare human variant that disrupts GPR10 signalling causes weight gain in mice.
Talbot F, Feetham CH, Mokrosiński J, Lawler K, Keogh JM, Henning E, Mendes de Oliveira E, Ayinampudi V, Saeed S, Bonnefond A, Arslan M, Yeo GSH, Froguel P, Bechtold DA, Adamson A, Humphreys N, Barroso I, Luckman SM, Farooqi IS. Talbot F, et al. Nat Commun. 2023 Mar 15;14(1):1450. doi: 10.1038/s41467-023-36966-3. Nat Commun. 2023. PMID: 36922513 Free PMC article.
Physiological Roles of GPR10 and PrRP Signaling.
Dodd GT, Luckman SM. Dodd GT, et al. Front Endocrinol (Lausanne). 2013 Mar 5;4:20. doi: 10.3389/fendo.2013.00020. eCollection 2013. Front Endocrinol (Lausanne). 2013. PMID: 23467899 Free PMC article.