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Page 1
2-Oxoglutarate-Dependent Oxygenases.
Islam MS, Leissing TM, Chowdhury R, Hopkinson RJ, Schofield CJ. Islam MS, et al. Annu Rev Biochem. 2018 Jun 20;87:585-620. doi: 10.1146/annurev-biochem-061516-044724. Epub 2018 Mar 1. Annu Rev Biochem. 2018. PMID: 29494239 Review.
Targeting Protein-Protein Interactions in the HIF System.
Wilkins SE, Abboud MI, Hancock RL, Schofield CJ. Wilkins SE, et al. ChemMedChem. 2016 Apr 19;11(8):773-86. doi: 10.1002/cmdc.201600012. Epub 2016 Mar 21. ChemMedChem. 2016. PMID: 26997519 Free PMC article. Review.
Inhibition of JMJD6 by 2-Oxoglutarate Mimics.
Islam MS, Thinnes CC, Holt-Martyn JP, Chowdhury R, McDonough MA, Schofield CJ. Islam MS, et al. ChemMedChem. 2022 Jan 5;17(1):e202100398. doi: 10.1002/cmdc.202100398. Epub 2021 Nov 16. ChemMedChem. 2022. PMID: 34581506 Free PMC article.
First-in-Class Inhibitors of the Ribosomal Oxygenase MINA53.
Nowak RP, Tumber A, Hendrix E, Ansari MSZ, Sabatino M, Antonini L, Andrijes R, Salah E, Mautone N, Pellegrini FR, Simelis K, Kawamura A, Johansson C, Passeri D, Pellicciari R, Ciogli A, Del Bufalo D, Ragno R, Coleman ML, Trisciuoglio D, Mai A, Oppermann U, Schofield CJ, Rotili D. Nowak RP, et al. J Med Chem. 2021 Dec 9;64(23):17031-17050. doi: 10.1021/acs.jmedchem.1c00605. Epub 2021 Nov 29. J Med Chem. 2021. PMID: 34843649 Free PMC article.
JMJD5 is a human arginyl C-3 hydroxylase.
Wilkins SE, Islam MS, Gannon JM, Markolovic S, Hopkinson RJ, Ge W, Schofield CJ, Chowdhury R. Wilkins SE, et al. Nat Commun. 2018 Mar 21;9(1):1180. doi: 10.1038/s41467-018-03410-w. Nat Commun. 2018. PMID: 29563586 Free PMC article.
The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases.
Markolovic S, Zhuang Q, Wilkins SE, Eaton CD, Abboud MI, Katz MJ, McNeil HE, Leśniak RK, Hall C, Struwe WB, Konietzny R, Davis S, Yang M, Ge W, Benesch JLP, Kessler BM, Ratcliffe PJ, Cockman ME, Fischer R, Wappner P, Chowdhury R, Coleman ML, Schofield CJ. Markolovic S, et al. Nat Chem Biol. 2018 Jul;14(7):688-695. doi: 10.1038/s41589-018-0071-y. Epub 2018 Jun 18. Nat Chem Biol. 2018. PMID: 29915238 Free PMC article.
36 results