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Signaling by the phosphoinositide 3-kinase family in immune cells.
Annu Rev Immunol. 2013;31:675-704. doi: 10.1146/annurev-immunol-032712-095946. Epub 2013 Jan 16.
Annu Rev Immunol. 2013.
PMID: 23330955
Free PMC article.
Review.
The PI3K isoforms p110alpha and p110delta are essential for pre-B cell receptor signaling and B cell development.
Ramadani F, Bolland DJ, Garcon F, Emery JL, Vanhaesebroeck B, Corcoran AE, Okkenhaug K.
Ramadani F, et al.
Sci Signal. 2010 Aug 10;3(134):ra60. doi: 10.1126/scisignal.2001104.
Sci Signal. 2010.
PMID: 20699475
Free PMC article.
Item in Clipboard
Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.
Selman C, Tullet JM, Wieser D, Irvine E, Lingard SJ, Choudhury AI, Claret M, Al-Qassab H, Carmignac D, Ramadani F, Woods A, Robinson IC, Schuster E, Batterham RL, Kozma SC, Thomas G, Carling D, Okkenhaug K, Thornton JM, Partridge L, Gems D, Withers DJ.
Selman C, et al.
Science. 2009 Oct 2;326(5949):140-4. doi: 10.1126/science.1177221.
Science. 2009.
PMID: 19797661
Free PMC article.
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PI3Kβ plays a critical role in neutrophil activation by immune complexes.
Kulkarni S, Sitaru C, Jakus Z, Anderson KE, Damoulakis G, Davidson K, Hirose M, Juss J, Oxley D, Chessa TA, Ramadani F, Guillou H, Segonds-Pichon A, Fritsch A, Jarvis GE, Okkenhaug K, Ludwig R, Zillikens D, Mocsai A, Vanhaesebroeck B, Stephens LR, Hawkins PT.
Kulkarni S, et al.
Sci Signal. 2011 Apr 12;4(168):ra23. doi: 10.1126/scisignal.2001617.
Sci Signal. 2011.
PMID: 21487106
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Rules of engagement: distinct functions for the four class I PI3K catalytic isoforms in immunity.
Okkenhaug K.
Okkenhaug K.
Ann N Y Acad Sci. 2013 Mar;1280:24-6. doi: 10.1111/nyas.12027.
Ann N Y Acad Sci. 2013.
PMID: 23551098
Free PMC article.
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Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice.
Selman C, Lingard S, Choudhury AI, Batterham RL, Claret M, Clements M, Ramadani F, Okkenhaug K, Schuster E, Blanc E, Piper MD, Al-Qassab H, Speakman JR, Carmignac D, Robinson IC, Thornton JM, Gems D, Partridge L, Withers DJ.
Selman C, et al.
FASEB J. 2008 Mar;22(3):807-18. doi: 10.1096/fj.07-9261com. Epub 2007 Oct 10.
FASEB J. 2008.
PMID: 17928362
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The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma.
Guillermet-Guibert J, Bjorklof K, Salpekar A, Gonella C, Ramadani F, Bilancio A, Meek S, Smith AJ, Okkenhaug K, Vanhaesebroeck B.
Guillermet-Guibert J, et al.
Proc Natl Acad Sci U S A. 2008 Jun 17;105(24):8292-7. doi: 10.1073/pnas.0707761105. Epub 2008 Jun 10.
Proc Natl Acad Sci U S A. 2008.
PMID: 18544649
Free PMC article.
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