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Enhanced production of taxadiene in Saccharomyces cerevisiae.
Nowrouzi B, Li RA, Walls LE, d'Espaux L, Malcı K, Liang L, Jonguitud-Borrego N, Lerma-Escalera AI, Morones-Ramirez JR, Keasling JD, Rios-Solis L. Nowrouzi B, et al. Microb Cell Fact. 2020 Nov 2;19(1):200. doi: 10.1186/s12934-020-01458-2. Microb Cell Fact. 2020. PMID: 33138820 Free PMC article.
BACKGROUND: Cost-effective production of the highly effective anti-cancer drug, paclitaxel (Taxol()), remains limited despite growing global demands. ...
BACKGROUND: Cost-effective production of the highly effective anti-cancer drug, paclitaxel (Taxol()), remains limited despite growing …
Integrated molecular characterisation of endometrioid ovarian carcinoma identifies opportunities for stratification.
Hollis RL, Stanley B, Thomson JP, Churchman M, Croy I, Rye T, Bartos C, Nussey F, Mackean M, Meynert AM, Semple CA, Gourley C, Herrington CS. Hollis RL, et al. NPJ Precis Oncol. 2021 Jun 2;5(1):47. doi: 10.1038/s41698-021-00187-y. NPJ Precis Oncol. 2021. PMID: 34079052 Free PMC article.
Endometrioid ovarian carcinoma (EnOC) is an under-investigated ovarian cancer type. Recent studies have described disease subtypes defined by genomics and hormone receptor expression patterns; here, we determine the relationship between these subtyping layers to define the …
Endometrioid ovarian carcinoma (EnOC) is an under-investigated ovarian cancer type. Recent studies have described disease subtypes de …
The oncogene Gankyrin is expressed in testicular cancer and contributes to cisplatin sensitivity in embryonal carcinoma cells.
Camacho-Moll ME, Macdonald J, Looijenga LHJ, Rimmer MP, Donat R, Marwick JA, Shukla CJ, Carragher N, Jørgensen A, Mitchell RT. Camacho-Moll ME, et al. BMC Cancer. 2019 Nov 19;19(1):1124. doi: 10.1186/s12885-019-6340-7. BMC Cancer. 2019. PMID: 31744479 Free PMC article.
BACKGROUND: Testicular germ cell cancer (TGCC) develops from pre-malignant germ neoplasia in situ (GCNIS) cells. ...
BACKGROUND: Testicular germ cell cancer (TGCC) develops from pre-malignant germ neoplasia in situ (GCNIS) cells. ...
Partial reprogramming induces a steady decline in epigenetic age before loss of somatic identity.
Olova N, Simpson DJ, Marioni RE, Chandra T. Olova N, et al. Aging Cell. 2019 Feb;18(1):e12877. doi: 10.1111/acel.12877. Epub 2018 Nov 18. Aging Cell. 2019. PMID: 30450724 Free PMC article.
., "younger" cells), rather than dedifferentiation, which bears the risk of cancer? Here, we analyse the dynamics of cellular age during human iPSC reprogramming and find that partial reprogramming leads to a reduction in the epigenetic age of cells. We also find that the …
., "younger" cells), rather than dedifferentiation, which bears the risk of cancer? Here, we analyse the dynamics of cellular age dur …
Biomarkers of systemic inflammation provide additional prognostic stratification in cancers of unknown primary.
Harvey S, Stares M, Scott JA, Thottiyil TJV, Conway AM, Haigh R, Brown J, Knowles G, Dasgupta S, Shiu KK, Mitchell C, Barrie C, Cook N, Clive S. Harvey S, et al. Cancer Med. 2024 Feb;13(3):e6988. doi: 10.1002/cam4.6988. Cancer Med. 2024. PMID: 38404120 Free PMC article.
BACKGROUND: Biomarkers of systemic inflammation have been shown to predict outcomes in patients with cancer of unknown primary (CUP). We sought to validate these findings in patients with confirmed CUP (cCUP) and explore their role alongside existing clinicopathological pr …
BACKGROUND: Biomarkers of systemic inflammation have been shown to predict outcomes in patients with cancer of unknown primary (CUP). …