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Apolipoprotein E in Alzheimer's disease and other neurological disorders.
Lancet Neurol. 2011 Mar;10(3):241-52. doi: 10.1016/S1474-4422(10)70325-2.
Lancet Neurol. 2011.
PMID: 21349439
Free PMC article.
Review.
ApoE influences amyloid-β (Aβ) clearance despite minimal apoE/Aβ association in physiological conditions.
Verghese PB, Castellano JM, Garai K, Wang Y, Jiang H, Shah A, Bu G, Frieden C, Holtzman DM.
Verghese PB, et al.
Proc Natl Acad Sci U S A. 2013 May 7;110(19):E1807-16. doi: 10.1073/pnas.1220484110. Epub 2013 Apr 25.
Proc Natl Acad Sci U S A. 2013.
PMID: 23620513
Free PMC article.
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Human apoE isoforms differentially regulate brain amyloid-β peptide clearance.
Castellano JM, Kim J, Stewart FR, Jiang H, DeMattos RB, Patterson BW, Fagan AM, Morris JC, Mawuenyega KG, Cruchaga C, Goate AM, Bales KR, Paul SM, Bateman RJ, Holtzman DM.
Castellano JM, et al.
Sci Transl Med. 2011 Jun 29;3(89):89ra57. doi: 10.1126/scitranslmed.3002156.
Sci Transl Med. 2011.
PMID: 21715678
Free PMC article.
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Low-density lipoprotein receptor overexpression enhances the rate of brain-to-blood Aβ clearance in a mouse model of β-amyloidosis.
Castellano JM, Deane R, Gottesdiener AJ, Verghese PB, Stewart FR, West T, Paoletti AC, Kasper TR, DeMattos RB, Zlokovic BV, Holtzman DM.
Castellano JM, et al.
Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15502-7. doi: 10.1073/pnas.1206446109. Epub 2012 Aug 27.
Proc Natl Acad Sci U S A. 2012.
PMID: 22927427
Free PMC article.
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Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance.
Kim J, Castellano JM, Jiang H, Basak JM, Parsadanian M, Pham V, Mason SM, Paul SM, Holtzman DM.
Kim J, et al.
Neuron. 2009 Dec 10;64(5):632-44. doi: 10.1016/j.neuron.2009.11.013.
Neuron. 2009.
PMID: 20005821
Free PMC article.
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