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A unique covalent bond in basement membrane is a primordial innovation for tissue evolution.
Fidler AL, Vanacore RM, Chetyrkin SV, Pedchenko VK, Bhave G, Yin VP, Stothers CL, Rose KL, McDonald WH, Clark TA, Borza DB, Steele RE, Ivy MT; Aspirnauts; Hudson JK, Hudson BG. Fidler AL, et al. Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):331-6. doi: 10.1073/pnas.1318499111. Epub 2013 Dec 16. Proc Natl Acad Sci U S A. 2014. PMID: 24344311 Free PMC article.
Integrin-free tetraspanin CD151 can inhibit tumor cell motility upon clustering and is a clinical indicator of prostate cancer progression.
Palmer TD, Martínez CH, Vasquez C, Hebron KE, Jones-Paris C, Arnold SA, Chan SM, Chalasani V, Gomez-Lemus JA, Williams AK, Chin JL, Giannico GA, Ketova T, Lewis JD, Zijlstra A. Palmer TD, et al. Cancer Res. 2014 Jan 1;74(1):173-87. doi: 10.1158/0008-5472.CAN-13-0275. Epub 2013 Nov 12. Cancer Res. 2014. PMID: 24220242 Free PMC article.