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Short-chain fatty acid producers in the gut are associated with pediatric multiple sclerosis onset.
Schoeps VA, Zhou X, Horton MK, Zhu F, McCauley KE, Nasr Z, Virupakshaiah A, Gorman MP, Benson LA, Weinstock-Guttman B, Waldman A, Banwell BL, Bar-Or A, Marrie RA, van Domselaar G, O'Mahony J, Mirza AI, Bernstein CN, Yeh EA, Casper TC, Lynch SV, Tremlett H, Baranzini S, Waubant E; US Network of Pediatric MS Centers. Schoeps VA, et al. Ann Clin Transl Neurol. 2024 Jan;11(1):169-184. doi: 10.1002/acn3.51944. Epub 2023 Nov 13. Ann Clin Transl Neurol. 2024. PMID: 37955284 Free PMC article.
Gut microbiome is associated with multiple sclerosis activity in children.
Horton MK, McCauley K, Fadrosh D, Fujimura K, Graves J, Ness J, Wheeler Y, Gorman MP, Benson LA, Weinstock-Guttman B, Waldman A, Rodriguez M, Tillema JM, Krupp L, Belman A, Mar S, Rensel M, Chitnis T, Casper TC, Rose J, Hart J, Shao X, Tremlett H, Lynch SV, Barcellos LF, Waubant E; U.S. Network of Pediatric MS Centers. Horton MK, et al. Ann Clin Transl Neurol. 2021 Sep;8(9):1867-1883. doi: 10.1002/acn3.51441. Epub 2021 Aug 19. Ann Clin Transl Neurol. 2021. PMID: 34409759 Free PMC article.
Rare and low-frequency coding genetic variants contribute to pediatric-onset multiple sclerosis.
Horton MK, Shim JE, Wallace A, Graves JS, Aaen G, Greenberg B, Mar S, Wheeler Y, Weinstock-Guttman B, Waldman A, Schreiner T, Rodriguez M, Tillema JM, Chitnis T, Krupp L, Casper TC, Rensel M, Hart J, Quach HL, Quach DL, Schaefer C, Waubant E, Barcellos LF. Horton MK, et al. Mult Scler. 2023 Apr;29(4-5):505-511. doi: 10.1177/13524585221150736. Epub 2023 Feb 8. Mult Scler. 2023. PMID: 36755464 Free PMC article.