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Single-cell dissection of the obesity-exercise axis in adipose-muscle tissues implies a critical role for mesenchymal stem cells.
Yang J, Vamvini M, Nigro P, Ho LL, Galani K, Alvarez M, Tanigawa Y, Renfro A, Carbone NP, Laakso M, Agudelo LZ, Pajukanta P, Hirshman MF, Middelbeek RJW, Grove K, Goodyear LJ, Kellis M. Yang J, et al. Cell Metab. 2022 Oct 4;34(10):1578-1593.e6. doi: 10.1016/j.cmet.2022.09.004. Cell Metab. 2022. PMID: 36198295 Free PMC article.
Exercise training remodels inguinal white adipose tissue through adaptations in innervation, vascularization, and the extracellular matrix.
Nigro P, Vamvini M, Yang J, Caputo T, Ho LL, Carbone NP, Papadopoulos D, Conlin R, He J, Hirshman MF, White JD, Robidoux J, Hickner RC, Nielsen S, Pedersen BK, Kellis M, Middelbeek RJW, Goodyear LJ. Nigro P, et al. Cell Rep. 2023 Apr 25;42(4):112392. doi: 10.1016/j.celrep.2023.112392. Epub 2023 Apr 13. Cell Rep. 2023. PMID: 37058410 Free PMC article.
Exercise Training Promotes Sex-Specific Adaptations in Mouse Inguinal White Adipose Tissue.
Nigro P, Middelbeek RJW, Alves CRR, Rovira-Llopis S, Ramachandran K, Rowland LA, Møller AB, Takahashi H, Alves-Wagner AB, Vamvini M, Makarewicz NS, Albertson BG, Hirshman MF, Goodyear LJ. Nigro P, et al. Diabetes. 2021 Jun;70(6):1250-1264. doi: 10.2337/db20-0790. Epub 2021 Feb 9. Diabetes. 2021. PMID: 33563587 Free PMC article.