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NEI's audacious goals initiative.
Salowe RJ, O'Brien JM. Salowe RJ, et al. Ophthalmology. 2014 Mar;121(3):615-6. doi: 10.1016/j.ophtha.2013.11.011. Ophthalmology. 2014. PMID: 24581751 No abstract available.
Synthesis of N-phenyl-N-(3-(piperidin-1-yl)propyl)benzofuran-2-carboxamides as new selective ligands for sigma receptors.
Marriott KS, Morrison AZ, Moore M, Olubajo O, Stewart LE. Marriott KS, et al. Bioorg Med Chem. 2012 Dec 1;20(23):6856-61. doi: 10.1016/j.bmc.2012.09.044. Epub 2012 Sep 29. Bioorg Med Chem. 2012. PMID: 23084435 Free PMC article.
Novel benzofuran-2-carboxamide ligands, which are selective for sigma receptors, have been synthesized via a microwave-assisted Perkin rearrangement reaction and a modified Finkelstein halogen-exchange used to facilitate N-alkylation. The ligands synthesized are the 3-meth …
Novel benzofuran-2-carboxamide ligands, which are selective for sigma receptors, have been synthesized via a microwave-assisted Perkin rearr …
Preliminary pharmacological evaluation of enantiomeric morphinans.
Sromek AW, Provencher BA, Russell S, Chartoff E, Knapp BI, Bidlack JM, Neumeyer JL. Sromek AW, et al. ACS Chem Neurosci. 2014 Feb 19;5(2):93-9. doi: 10.1021/cn400205z. Epub 2014 Jan 8. ACS Chem Neurosci. 2014. PMID: 24393077 Free PMC article.
A series of levo- and dextromorphinan pairs have been synthesized and evaluated for their affinities to the mu, kappa, and delta opioid receptors, the N-methyl-D-aspartate (NMDA) channel, and sigma 1 and 2 receptors. ...
A series of levo- and dextromorphinan pairs have been synthesized and evaluated for their affinities to the mu, kappa, and delta opioid rece …
Motor assessment using the NIH Toolbox.
Reuben DB, Magasi S, McCreath HE, Bohannon RW, Wang YC, Bubela DJ, Rymer WZ, Beaumont J, Rine RM, Lai JS, Gershon RC. Reuben DB, et al. Neurology. 2013 Mar 12;80(11 Suppl 3):S65-75. doi: 10.1212/WNL.0b013e3182872e01. Neurology. 2013. PMID: 23479547 Free PMC article.
Motor function involves complex physiologic processes and requires the integration of multiple systems, including neuromuscular, musculoskeletal, and cardiopulmonary, and neural motor and sensory-perceptual systems. Motor-functional status is indicative of current physical hea …
Motor function involves complex physiologic processes and requires the integration of multiple systems, including neuromuscular, musculoskel …
Tetrahydroprotoberberine alkaloids with dopamine and σ receptor affinity.
Gadhiya S, Madapa S, Kurtzman T, Alberts IL, Ramsey S, Pillarsetty NK, Kalidindi T, Harding WW. Gadhiya S, et al. Bioorg Med Chem. 2016 May 1;24(9):2060-71. doi: 10.1016/j.bmc.2016.03.037. Epub 2016 Mar 21. Bioorg Med Chem. 2016. PMID: 27032890 Free PMC article.
Two series of analogues of the tetrahydroprotoberberine (THPB) alkaloid ()-stepholidine that (a) contain various alkoxy substituents at the C10 position and, (b) were de-rigidified with respect to ()-stepholidine, were synthesized and evaluated for affinity at dopamine and sigma …
Two series of analogues of the tetrahydroprotoberberine (THPB) alkaloid ()-stepholidine that (a) contain various alkoxy substituents at the …
183 results