HL082670/HL/NHLBI NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2007	1
2008	3
2009	4
2010	4
2011	1
2024	0

1

Protein tyrosine phosphatases in the JAK/STAT pathway.

Xu D, Qu CK. Xu D, et al. Front Biosci. 2008 May 1;13:4925-32. doi: 10.2741/3051. Front Biosci. 2008. PMID: 18508557 Free PMC article. Review.

2

SHP-2 tyrosine phosphatase in human diseases.

Zheng H, Alter S, Qu CK. Zheng H, et al. Int J Clin Exp Med. 2009;2(1):17-25. Epub 2009 Jan 30. Int J Clin Exp Med. 2009. PMID: 19436828 Free PMC article.

3

Tyr66 acts as a conformational switch in the closed-to-open transition of the SHP-2 N-SH2-domain phosphotyrosine-peptide binding cleft.

Guvench O, Qu CK, MacKerell AD Jr. Guvench O, et al. BMC Struct Biol. 2007 Mar 22;7:14. doi: 10.1186/1472-6807-7-14. BMC Struct Biol. 2007. PMID: 17378938 Free PMC article.

4

Structural mechanism associated with domain opening in gain-of-function mutations in SHP2 phosphatase.

Darian E, Guvench O, Yu B, Qu CK, MacKerell AD Jr. Darian E, et al. Proteins. 2011 May;79(5):1573-88. doi: 10.1002/prot.22984. Epub 2011 Mar 1. Proteins. 2011. PMID: 21365683 Free PMC article.

5

Deficiency of MIP/MTMR14 phosphatase induces a muscle disorder by disrupting Ca(2+) homeostasis.

Shen J, Yu WM, Brotto M, Scherman JA, Guo C, Stoddard C, Nosek TM, Valdivia HH, Qu CK. Shen J, et al. Nat Cell Biol. 2009 Jun;11(6):769-76. doi: 10.1038/ncb1884. Epub 2009 May 24. Nat Cell Biol. 2009. PMID: 19465920 Free PMC article.

6

A small-molecule inhibitor of BCL6 kills DLBCL cells in vitro and in vivo.

Cerchietti LC, Ghetu AF, Zhu X, Da Silva GF, Zhong S, Matthews M, Bunting KL, Polo JM, Farès C, Arrowsmith CH, Yang SN, Garcia M, Coop A, Mackerell AD Jr, Privé GG, Melnick A. Cerchietti LC, et al. Cancer Cell. 2010 Apr 13;17(4):400-11. doi: 10.1016/j.ccr.2009.12.050. Cancer Cell. 2010. PMID: 20385364 Free PMC article.

7

Computational evaluation of protein-small molecule binding.

Guvench O, MacKerell AD Jr. Guvench O, et al. Curr Opin Struct Biol. 2009 Feb;19(1):56-61. doi: 10.1016/j.sbi.2008.11.009. Epub 2009 Jan 21. Curr Opin Struct Biol. 2009. PMID: 19162472 Free PMC article.

8

Noonan syndrome/leukemia-associated gain-of-function mutations in SHP-2 phosphatase (PTPN11) enhance cell migration and angiogenesis.

Wang S, Yu WM, Zhang W, McCrae KR, Neel BG, Qu CK. Wang S, et al. J Biol Chem. 2009 Jan 9;284(2):913-20. doi: 10.1074/jbc.M804129200. Epub 2008 Nov 13. J Biol Chem. 2009. PMID: 19008228 Free PMC article.

9

A germline gain-of-function mutation in Ptpn11 (Shp-2) phosphatase induces myeloproliferative disease by aberrant activation of hematopoietic stem cells.

Xu D, Wang S, Yu WM, Chan G, Araki T, Bunting KD, Neel BG, Qu CK. Xu D, et al. Blood. 2010 Nov 4;116(18):3611-21. doi: 10.1182/blood-2010-01-265652. Epub 2010 Jul 22. Blood. 2010. PMID: 20651068 Free PMC article.

10

Muscle-specific inositide phosphatase (MIP/MTMR14) is reduced with age and its loss accelerates skeletal muscle aging process by altering calcium homeostasis.

Romero-Suarez S, Shen J, Brotto L, Hall T, Mo C, Valdivia HH, Andresen J, Wacker M, Nosek TM, Qu CK, Brotto M. Romero-Suarez S, et al. Aging (Albany NY). 2010 Aug;2(8):504-13. doi: 10.18632/aging.100190. Aging (Albany NY). 2010. PMID: 20817957 Free PMC article.

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