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Empagliflozin reduces high glucose-induced oxidative stress and miR-21-dependent TRAF3IP2 induction and RECK suppression, and inhibits human renal proximal tubular epithelial cell migration and epithelial-to-mesenchymal transition.
Das NA, Carpenter AJ, Belenchia A, Aroor AR, Noda M, Siebenlist U, Chandrasekar B, DeMarco VG. Das NA, et al. Cell Signal. 2020 Apr;68:109506. doi: 10.1016/j.cellsig.2019.109506. Epub 2019 Dec 17. Cell Signal. 2020. PMID: 31862399 Free PMC article.
TRAF3IP2, a novel therapeutic target in glioblastoma multiforme.
Alt EU, Barabadi Z, Pfnür A, Ochoa JE, Daneshimehr F, Lang LM, Lin D, Braun SE, Chandrasekar B, Izadpanah R. Alt EU, et al. Oncotarget. 2018 Jul 3;9(51):29772-29788. doi: 10.18632/oncotarget.25710. eCollection 2018 Jul 3. Oncotarget. 2018. PMID: 30038719 Free PMC article.
The SGLT2 inhibitor Empagliflozin attenuates interleukin-17A-induced human aortic smooth muscle cell proliferation and migration by targeting TRAF3IP2/ROS/NLRP3/Caspase-1-dependent IL-1β and IL-18 secretion.
Sukhanov S, Higashi Y, Yoshida T, Mummidi S, Aroor AR, Jeffrey Russell J, Bender SB, DeMarco VG, Chandrasekar B. Sukhanov S, et al. Cell Signal. 2021 Jan;77:109825. doi: 10.1016/j.cellsig.2020.109825. Epub 2020 Nov 4. Cell Signal. 2021. PMID: 33160017 Free PMC article.
21 results