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Killer-cell Immunoglobulin-like Receptor (KIR) gene profiles modify HIV disease course, not HIV acquisition in South African women.
Naranbhai V, de Assis Rosa D, Werner L, Moodley R, Hong H, Kharsany A, Mlisana K, Sibeko S, Garrett N, Chopera D, Carr WH, Abdool Karim Q, Hill AV, Abdool Karim SS, Altfeld M, Gray CM, Ndung'u T. Naranbhai V, et al. BMC Infect Dis. 2016 Jan 25;16:27. doi: 10.1186/s12879-016-1361-1. BMC Infect Dis. 2016. PMID: 26809736 Free PMC article.
Neither microbial translocation nor TLR responsiveness are likely explanations for preexisting immune activation in women who subsequently acquired HIV in CAPRISA 004.
Naranbhai V, Samsunder N, Sandler NG, Roque A, Abdool Karim Q, Ndungʼu T, Carr WH, Altfeld M, Douek DC, Abdool Karim SS; CAPRISA 004 Trial Team. Naranbhai V, et al. J Acquir Immune Defic Syndr. 2013 Jul 1;63(3):294-8. doi: 10.1097/QAI.0b013e31828e604b. J Acquir Immune Defic Syndr. 2013. PMID: 23481666 Free PMC article. Clinical Trial.
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