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2021 5
2022 2
2023 2
2024 0

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Platform Randomised trial of INterventions against COVID-19 In older peoPLE (PRINCIPLE): protocol for a randomised, controlled, open-label, adaptive platform, trial of community treatment of COVID-19 syndromic illness in people at higher risk.
Hayward G, Butler CC, Yu LM, Saville BR, Berry N, Dorward J, Gbinigie O, van Hecke O, Ogburn E, Swayze H, Bongard E, Allen J, Tonner S, Rutter H, Tonkin-Crine S, Borek A, Judge D, Grabey J, de Lusignan S, Thomas NPB, Evans PH, Andersson MI, Llewelyn M, Patel M, Hopkins S, Hobbs FDR. Hayward G, et al. BMJ Open. 2021 Jun 18;11(6):e046799. doi: 10.1136/bmjopen-2020-046799. BMJ Open. 2021. PMID: 34145016 Free PMC article.
Development and evaluation of rapid data-enabled access to routine clinical information to enhance early recruitment to the national clinical platform trial of COVID-19 community treatments.
Cake C, Ogburn E, Pinches H, Coleman G, Seymour D, Woodard F, Manohar S, Monsur M, Landray M, Dalton G, Morris AD, Chinnery PF; UK COVID-19 National Core Studies Consortium; Hobbs FDR, Butler C. Cake C, et al. Trials. 2022 Jan 20;23(1):62. doi: 10.1186/s13063-021-05965-4. Trials. 2022. PMID: 35057841 Free PMC article.
Doxycycline for community treatment of suspected COVID-19 in people at high risk of adverse outcomes in the UK (PRINCIPLE): a randomised, controlled, open-label, adaptive platform trial.
Butler CC, Yu LM, Dorward J, Gbinigie O, Hayward G, Saville BR, Van Hecke O, Berry N, Detry MA, Saunders C, Fitzgerald M, Harris V, Djukanovic R, Gadola S, Kirkpatrick J, de Lusignan S, Ogburn E, Evans PH, Thomas NPB, Patel MG, Hobbs FDR; PRINCIPLE Trial Collaborative Group. Butler CC, et al. Lancet Respir Med. 2021 Sep;9(9):1010-1020. doi: 10.1016/S2213-2600(21)00310-6. Epub 2021 Jul 27. Lancet Respir Med. 2021. PMID: 34329624 Free PMC article. Clinical Trial.
Colchicine for COVID-19 in the community (PRINCIPLE): a randomised, controlled, adaptive platform trial.
Dorward J, Yu LM, Hayward G, Saville BR, Gbinigie O, Van Hecke O, Ogburn E, Evans PH, Thomas NP, Patel MG, Richards D, Berry N, Detry MA, Saunders C, Fitzgerald M, Harris V, Shanyinde M, de Lusignan S, Andersson MI, Butler CC, Hobbs FR; PRINCIPLE Trial Collaborative Group. Dorward J, et al. Br J Gen Pract. 2022 Jun 30;72(720):e446-e455. doi: 10.3399/BJGP.2022.0083. Print 2022 Jul. Br J Gen Pract. 2022. PMID: 35440469 Free PMC article. Clinical Trial.
Inhaled budesonide for COVID-19 in people at high risk of complications in the community in the UK (PRINCIPLE): a randomised, controlled, open-label, adaptive platform trial.
Yu LM, Bafadhel M, Dorward J, Hayward G, Saville BR, Gbinigie O, Van Hecke O, Ogburn E, Evans PH, Thomas NPB, Patel MG, Richards D, Berry N, Detry MA, Saunders C, Fitzgerald M, Harris V, Shanyinde M, de Lusignan S, Andersson MI, Barnes PJ, Russell REK, Nicolau DV Jr, Ramakrishnan S, Hobbs FDR, Butler CC; PRINCIPLE Trial Collaborative Group. Yu LM, et al. Lancet. 2021 Sep 4;398(10303):843-855. doi: 10.1016/S0140-6736(21)01744-X. Epub 2021 Aug 10. Lancet. 2021. PMID: 34388395 Free PMC article. Clinical Trial.
High-dose budesonide for early COVID-19 - Authors' reply.
Hobbs FDR, Yu LM, Saville BR, Bafadhel M, Butler CC. Hobbs FDR, et al. Lancet. 2021 Dec 11;398(10317):2147-2148. doi: 10.1016/S0140-6736(21)02449-1. Lancet. 2021. PMID: 34895528 Free PMC article. No abstract available.
Correction: Development and evaluation of rapid data-enabled access to routine clinical information to enhance early recruitment to the national clinical platform trial of COVID-19 community treatments.
Cake C, Ogburn E, Pinches H, Coleman G, Seymour D, Woodard F, Manohar S, Monsur M, Landray M, Dalton G, Morris AD, Chinnery PF; UK COVID-19 National Core Studies Consortium; Hobbs FDR, Butler C. Cake C, et al. Trials. 2023 Sep 19;24(1):598. doi: 10.1186/s13063-023-07606-4. Trials. 2023. PMID: 37726825 Free PMC article. No abstract available.