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Optimal translational termination requires C4 lysyl hydroxylation of eRF1.
Feng T, Yamamoto A, Wilkins SE, Sokolova E, Yates LA, Münzel M, Singh P, Hopkinson RJ, Fischer R, Cockman ME, Shelley J, Trudgian DC, Schödel J, McCullagh JS, Ge W, Kessler BM, Gilbert RJ, Frolova LY, Alkalaeva E, Ratcliffe PJ, Schofield CJ, Coleman ML. Feng T, et al. Mol Cell. 2014 Feb 20;53(4):645-54. doi: 10.1016/j.molcel.2013.12.028. Epub 2014 Jan 30. Mol Cell. 2014. PMID: 24486019 Free PMC article.
Modifying the maker: Oxygenases target ribosome biology.
Zhuang Q, Feng T, Coleman ML. Zhuang Q, et al. Translation (Austin). 2015 Feb 3;3(1):e1009331. doi: 10.1080/21690731.2015.1009331. eCollection 2015 Jan-Jun. Translation (Austin). 2015. PMID: 26779412 Free PMC article.
OGFOD1 catalyzes prolyl hydroxylation of RPS23 and is involved in translation control and stress granule formation.
Singleton RS, Liu-Yi P, Formenti F, Ge W, Sekirnik R, Fischer R, Adam J, Pollard PJ, Wolf A, Thalhammer A, Loenarz C, Flashman E, Yamamoto A, Coleman ML, Kessler BM, Wappner P, Schofield CJ, Ratcliffe PJ, Cockman ME. Singleton RS, et al. Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4031-6. doi: 10.1073/pnas.1314482111. Epub 2014 Feb 18. Proc Natl Acad Sci U S A. 2014. PMID: 24550447 Free PMC article.