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Year | Number of Results |
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Page 1
GEFs: Dual regulation of Rac1 signaling.
Small GTPases. 2017 Apr 3;8(2):90-99. doi: 10.1080/21541248.2016.1202635. Epub 2016 Jun 17.
Small GTPases. 2017.
PMID: 27314616
Free PMC article.
Review.
Deregulation of Rho GTPases in cancer.
Porter AP, Papaioannou A, Malliri A.
Porter AP, et al.
Small GTPases. 2016 Jul 2;7(3):123-38. doi: 10.1080/21541248.2016.1173767. Epub 2016 Apr 22.
Small GTPases. 2016.
PMID: 27104658
Free PMC article.
Review.
Item in Clipboard
Rac1 in human diseases: The therapeutic potential of targeting Rac1 signaling regulatory mechanisms.
Marei H, Malliri A.
Marei H, et al.
Small GTPases. 2017 Jul 3;8(3):139-163. doi: 10.1080/21541248.2016.1211398. Epub 2016 Jul 21.
Small GTPases. 2017.
PMID: 27442895
Free PMC article.
Review.
Item in Clipboard
STEF/TIAM2-mediated Rac1 activity at the nuclear envelope regulates the perinuclear actin cap.
Woroniuk A, Porter A, White G, Newman DT, Diamantopoulou Z, Waring T, Rooney C, Strathdee D, Marston DJ, Hahn KM, Sansom OJ, Zech T, Malliri A.
Woroniuk A, et al.
Nat Commun. 2018 May 29;9(1):2124. doi: 10.1038/s41467-018-04404-4.
Nat Commun. 2018.
PMID: 29844364
Free PMC article.
Item in Clipboard
HUWE1 ubiquitylates and degrades the RAC activator TIAM1 promoting cell-cell adhesion disassembly, migration, and invasion.
Vaughan L, Tan CT, Chapman A, Nonaka D, Mack NA, Smith D, Booton R, Hurlstone AF, Malliri A.
Vaughan L, et al.
Cell Rep. 2015 Jan 6;10(1):88-102. doi: 10.1016/j.celrep.2014.12.012. Epub 2014 Dec 24.
Cell Rep. 2015.
PMID: 25543140
Free PMC article.
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TIAM1 Antagonizes TAZ/YAP Both in the Destruction Complex in the Cytoplasm and in the Nucleus to Inhibit Invasion of Intestinal Epithelial Cells.
Diamantopoulou Z, White G, Fadlullah MZH, Dreger M, Pickering K, Maltas J, Ashton G, MacLeod R, Baillie GS, Kouskoff V, Lacaud G, Murray GI, Sansom OJ, Hurlstone AFL, Malliri A.
Diamantopoulou Z, et al.
Cancer Cell. 2017 May 8;31(5):621-634.e6. doi: 10.1016/j.ccell.2017.03.007. Epub 2017 Apr 13.
Cancer Cell. 2017.
PMID: 28416184
Free PMC article.
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HUWE1 is a critical colonic tumour suppressor gene that prevents MYC signalling, DNA damage accumulation and tumour initiation.
Myant KB, Cammareri P, Hodder MC, Wills J, Von Kriegsheim A, Győrffy B, Rashid M, Polo S, Maspero E, Vaughan L, Gurung B, Barry E, Malliri A, Camargo F, Adams DJ, Iavarone A, Lasorella A, Sansom OJ.
Myant KB, et al.
EMBO Mol Med. 2017 Feb;9(2):181-197. doi: 10.15252/emmm.201606684.
EMBO Mol Med. 2017.
PMID: 28003334
Free PMC article.
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