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CXCR4-targeted nanotoxins induce GSDME-dependent pyroptosis in head and neck squamous cell carcinoma.
Rioja-Blanco E, Arroyo-Solera I, Álamo P, Casanova I, Gallardo A, Unzueta U, Serna N, Sánchez-García L, Quer M, Villaverde A, Vázquez E, León X, Alba-Castellón L, Mangues R. Rioja-Blanco E, et al. J Exp Clin Cancer Res. 2022 Feb 4;41(1):49. doi: 10.1186/s13046-022-02267-8. J Exp Clin Cancer Res. 2022. PMID: 35120582 Free PMC article.
Thus, novel therapeutic strategies are urgently needed. Targeted drug delivery to the chemokine receptor 4 (CXCR4) represents a promising approach for HNSCC management. In this context, we have developed the self-assembling protein nanotoxins T22-PE24-H6 and T22-DITOX-H6, …
Thus, novel therapeutic strategies are urgently needed. Targeted drug delivery to the chemokine receptor 4 (CXCR4) represents a promi …
Biparatopic Protein Nanoparticles for the Precision Therapy of CXCR4+ Cancers.
Cano-Garrido O, Álamo P, Sánchez-García L, Falgàs A, Sánchez-Chardi A, Serna N, Parladé E, Unzueta U, Roldán M, Voltà-Durán E, Casanova I, Villaverde A, Mangues R, Vázquez E. Cano-Garrido O, et al. Cancers (Basel). 2021 Jun 11;13(12):2929. doi: 10.3390/cancers13122929. Cancers (Basel). 2021. PMID: 34208189 Free PMC article.
The accumulated molecular knowledge about human cancer enables the identification of multiple cell surface markers as highly specific therapeutic targets. A proper tumor targeting could significantly avoid drug exposure of healthy cells, minimizing side effects, but …
The accumulated molecular knowledge about human cancer enables the identification of multiple cell surface markers as highly specific therap …
Structural Stabilization of Clinically Oriented Oligomeric Proteins During their Transit through Synthetic Secretory Amyloids.
Sánchez JM, López-Laguna H, Parladé E, Somma AD, Livieri AL, Álamo P, Mangues R, Unzueta U, Villaverde A, Vázquez E. Sánchez JM, et al. Adv Sci (Weinh). 2024 Mar 19:e2309427. doi: 10.1002/advs.202309427. Online ahead of print. Adv Sci (Weinh). 2024. PMID: 38501900
Developing time-sustained drug delivery systems is a main goal in innovative medicines. Inspired by the architecture of secretory granules from the mammalian endocrine system it has generated non-toxic microscale amyloid materials through the coordination between divalent …
Developing time-sustained drug delivery systems is a main goal in innovative medicines. Inspired by the architecture of secretory gra …