Abstract
Aging-induced declines in muscle size and quality are thought to contribute to catabolic alterations in bone, but changes in bone with age also profoundly alter its response to muscle-derived stimuli. This review provides an overview of some of the alterations that occur in muscle and bone with aging, and discusses the cellular and molecular mechanisms that may impact these age-associated changes.
©2015 Int. Union Physiol. Sci./Am. Physiol. Soc.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
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Review
MeSH terms
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Aging*
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Animals
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Bone and Bones / metabolism
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Bone and Bones / pathology*
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Calcification, Physiologic / physiology*
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Humans
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Muscle Fibers, Skeletal / cytology*
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Muscle Fibers, Skeletal / metabolism
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Muscle, Skeletal / metabolism
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Muscle, Skeletal / pathology*
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Muscular Diseases / metabolism
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Muscular Diseases / pathology
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Muscular Diseases / physiopathology