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Page 1
Mitochondrial dysfunction in cell senescence and aging.
Miwa S, Kashyap S, Chini E, von Zglinicki T. Miwa S, et al. J Clin Invest. 2022 Jul 1;132(13):e158447. doi: 10.1172/JCI158447. J Clin Invest. 2022. PMID: 35775483 Free PMC article. Review.
Evolving concepts in NAD+ metabolism.
Chini CCS, Zeidler JD, Kashyap S, Warner G, Chini EN. Chini CCS, et al. Cell Metab. 2021 Jun 1;33(6):1076-1087. doi: 10.1016/j.cmet.2021.04.003. Epub 2021 Apr 29. Cell Metab. 2021. PMID: 33930322 Free PMC article. Review.
p21 induces a senescence program and skeletal muscle dysfunction.
Englund DA, Jolliffe A, Aversa Z, Zhang X, Sturmlechner I, Sakamoto AE, Zeidler JD, Warner GM, McNinch C, White TA, Chini EN, Baker DJ, van Deursen JM, LeBrasseur NK. Englund DA, et al. Mol Metab. 2023 Jan;67:101652. doi: 10.1016/j.molmet.2022.101652. Epub 2022 Dec 9. Mol Metab. 2023. PMID: 36509362 Free PMC article.
CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels.
Chini CCS, Peclat TR, Warner GM, Kashyap S, Espindola-Netto JM, de Oliveira GC, Gomez LS, Hogan KA, Tarragó MG, Puranik AS, Agorrody G, Thompson KL, Dang K, Clarke S, Childs BG, Kanamori KS, Witte MA, Vidal P, Kirkland AL, De Cecco M, Chellappa K, McReynolds MR, Jankowski C, Tchkonia T, Kirkland JL, Sedivy JM, van Deursen JM, Baker DJ, van Schooten W, Rabinowitz JD, Baur JA, Chini EN. Chini CCS, et al. Nat Metab. 2020 Nov;2(11):1284-1304. doi: 10.1038/s42255-020-00298-z. Epub 2020 Nov 16. Nat Metab. 2020. PMID: 33199925 Free PMC article.
Targeting senescent cells alleviates obesity-induced metabolic dysfunction.
Palmer AK, Xu M, Zhu Y, Pirtskhalava T, Weivoda MM, Hachfeld CM, Prata LG, van Dijk TH, Verkade E, Casaclang-Verzosa G, Johnson KO, Cubro H, Doornebal EJ, Ogrodnik M, Jurk D, Jensen MD, Chini EN, Miller JD, Matveyenko A, Stout MB, Schafer MJ, White TA, Hickson LJ, Demaria M, Garovic V, Grande J, Arriaga EA, Kuipers F, von Zglinicki T, LeBrasseur NK, Campisi J, Tchkonia T, Kirkland JL. Palmer AK, et al. Aging Cell. 2019 Jun;18(3):e12950. doi: 10.1111/acel.12950. Epub 2019 Mar 25. Aging Cell. 2019. PMID: 30907060 Free PMC article.
NAD metabolism: Role in senescence regulation and aging.
Chini CCS, Cordeiro HS, Tran NLK, Chini EN. Chini CCS, et al. Aging Cell. 2024 Jan;23(1):e13920. doi: 10.1111/acel.13920. Epub 2023 Jul 9. Aging Cell. 2024. PMID: 37424179 Free PMC article. Review.
CD38-NADase is a new major contributor to Duchenne muscular dystrophic phenotype.
de Zélicourt A, Fayssoil A, Dakouane-Giudicelli M, De Jesus I, Karoui A, Zarrouki F, Lefebvre F, Mansart A, Launay JM, Piquereau J, Tarragó MG, Bonay M, Forand A, Moog S, Piétri-Rouxel F, Brisebard E, Chini CCS, Kashyap S, Fogarty MJ, Sieck GC, Mericskay M, Chini EN, Gomez AM, Cancela JM, de la Porte S. de Zélicourt A, et al. EMBO Mol Med. 2022 May 9;14(5):e12860. doi: 10.15252/emmm.202012860. Epub 2022 Mar 17. EMBO Mol Med. 2022. PMID: 35298089 Free PMC article.
Endogenous metabolism in endothelial and immune cells generates most of the tissue vitamin B3 (nicotinamide).
Zeidler JD, Chini CCS, Kanamori KS, Kashyap S, Espindola-Netto JM, Thompson K, Warner G, Cabral FS, Peclat TR, Gomez LS, Lopez SA, Wandersee MK, Schoon RA, Reid K, Menzies K, Beckedorff F, Reid JM, Brachs S, Meyer RG, Meyer-Ficca ML, Chini EN. Zeidler JD, et al. iScience. 2022 Oct 23;25(11):105431. doi: 10.1016/j.isci.2022.105431. eCollection 2022 Nov 18. iScience. 2022. PMID: 36388973 Free PMC article.
Metabolism in Male Reproductive Aging.
Meyer RG, Meyer-Ficca ML. Meyer RG, et al. Adv Geriatr Med Res. 2021;3(1):e210005. doi: 10.20900/agmr20210005. Epub 2021 Jan 12. Adv Geriatr Med Res. 2021. PMID: 33554222 Free PMC article.
34 results