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CR1 is associated with amyloid plaque burden and age-related cognitive decline.
Chibnik LB, Shulman JM, Leurgans SE, Schneider JA, Wilson RS, Tran D, Aubin C, Buchman AS, Heward CB, Myers AJ, Hardy JA, Huentelman MJ, Corneveaux JJ, Reiman EM, Evans DA, Bennett DA, De Jager PL. Chibnik LB, et al. Ann Neurol. 2011 Mar;69(3):560-9. doi: 10.1002/ana.22277. Epub 2011 Mar 9. Ann Neurol. 2011. PMID: 21391232 Free PMC article.
A coding variant in CR1 interacts with APOE-ε4 to influence cognitive decline.
Keenan BT, Shulman JM, Chibnik LB, Raj T, Tran D, Sabuncu MR; Alzheimer's Disease Neuroimaging Initiative; Allen AN, Corneveaux JJ, Hardy JA, Huentelman MJ, Lemere CA, Myers AJ, Nicholson-Weller A, Reiman EM, Evans DA, Bennett DA, De Jager PL. Keenan BT, et al. Hum Mol Genet. 2012 May 15;21(10):2377-88. doi: 10.1093/hmg/dds054. Epub 2012 Feb 17. Hum Mol Genet. 2012. PMID: 22343410 Free PMC article.
Genetic variation at CR1 increases risk of cerebral amyloid angiopathy.
Biffi A, Shulman JM, Jagiella JM, Cortellini L, Ayres AM, Schwab K, Brown DL, Silliman SL, Selim M, Worrall BB, Meschia JF, Slowik A, De Jager PL, Greenberg SM, Schneider JA, Bennett DA, Rosand J. Biffi A, et al. Neurology. 2012 Jan 31;78(5):334-41. doi: 10.1212/WNL.0b013e3182452b40. Epub 2012 Jan 18. Neurology. 2012. PMID: 22262751 Free PMC article.