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Encapsulation of an EP67-Conjugated CTL Peptide Vaccine in Nanoscale Biodegradable Particles Increases the Efficacy of Respiratory Immunization and Affects the Magnitude and Memory Subsets of Vaccine-Generated Mucosal and Systemic CD8+ T Cells in a Diameter-Dependent Manner.
Mol Pharm. 2017 May 1;14(5):1469-1481. doi: 10.1021/acs.molpharmaceut.6b01088. Epub 2017 Apr 3.
Mol Pharm. 2017.
PMID: 28319404
Free PMC article.
Targeted Amino Acid Substitution Overcomes Scale-Up Challenges with the Human C5a-Derived Decapeptide Immunostimulant EP67.
Alshammari AM, Smith DD, Parriott J, Stewart JP, Curran SM, McCulloh RJ, Barry PA, Iyer SS, Palermo N, Phillips JA, Dong Y, Ronning DR, Vennerstrom JL, Sanderson SD, Vetro JA.
Alshammari AM, et al.
ACS Infect Dis. 2020 May 8;6(5):1169-1181. doi: 10.1021/acsinfecdis.0c00005. Epub 2020 Apr 13.
ACS Infect Dis. 2020.
PMID: 32233506
Free PMC article.
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Surface Modification of Biodegradable Microparticles with the Novel Host-Derived Immunostimulant CPDI-02 Significantly Increases Short-Term and Long-Term Mucosal and Systemic Antibodies against Encapsulated Protein Antigen in Young Naïve Mice after Respiratory Immunization.
Parriott JE, Stewart JP, Smith DD, Curran SM, Bauer CD, Wyatt TA, Phillips JA, Lyden E, Thiele GM, Vetro JA.
Parriott JE, et al.
Pharmaceutics. 2022 Sep 1;14(9):1843. doi: 10.3390/pharmaceutics14091843.
Pharmaceutics. 2022.
PMID: 36145590
Free PMC article.
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Surface conjugation of EP67 to biodegradable nanoparticles increases the generation of long-lived mucosal and systemic memory T-cells by encapsulated protein vaccine after respiratory immunization and subsequent T-cell-mediated protection against respiratory infection.
Tallapaka SB, Karuturi BVK, Yeapuri P, Curran SM, Sonawane YA, Phillips JA, David Smith D, Sanderson SD, Vetro JA.
Tallapaka SB, et al.
Int J Pharm. 2019 Jun 30;565:242-257. doi: 10.1016/j.ijpharm.2019.05.012. Epub 2019 May 8.
Int J Pharm. 2019.
PMID: 31077762
Free PMC article.
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