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C. difficile intoxicates neurons and pericytes to drive neurogenic inflammation.
Manion J, Musser MA, Kuziel GA, Liu M, Shepherd A, Wang S, Lee PG, Zhao L, Zhang J, Marreddy RKR, Goldsmith JD, Yuan K, Hurdle JG, Gerhard R, Jin R, Rakoff-Nahoum S, Rao M, Dong M. Manion J, et al. Nature. 2023 Oct;622(7983):611-618. doi: 10.1038/s41586-023-06607-2. Epub 2023 Sep 12. Nature. 2023. PMID: 37699522
Emerging enterococcus pore-forming toxins with MHC/HLA-I as receptors.
Xiong X, Tian S, Yang P, Lebreton F, Bao H, Sheng K, Yin L, Chen P, Zhang J, Qi W, Ruan J, Wu H, Chen H, Breault DT, Wu H, Earl AM, Gilmore MS, Abraham J, Dong M. Xiong X, et al. Cell. 2022 Mar 31;185(7):1157-1171.e22. doi: 10.1016/j.cell.2022.02.002. Epub 2022 Mar 7. Cell. 2022. PMID: 35259335 Free PMC article.
CRISPR screens in Drosophila cells identify Vsg as a Tc toxin receptor.
Xu Y, Viswanatha R, Sitsel O, Roderer D, Zhao H, Ashwood C, Voelcker C, Tian S, Raunser S, Perrimon N, Dong M. Xu Y, et al. Nature. 2022 Oct;610(7931):349-355. doi: 10.1038/s41586-022-05250-7. Epub 2022 Sep 28. Nature. 2022. PMID: 36171290 Free PMC article.
Targeted inhibition of Wnt signaling with a Clostridioides difficile toxin B fragment suppresses breast cancer tumor growth.
He A, Tian S, Kopper O, Horan DJ, Chen P, Bronson RT, Sheng R, Wu H, Sui L, Zhou K, Tao L, Wu Q, Huang Y, Shen Z, Han S, Chen X, Chen H, He X, Robling AG, Jin R, Clevers H, Xiang D, Li Z, Dong M. He A, et al. PLoS Biol. 2023 Nov 9;21(11):e3002353. doi: 10.1371/journal.pbio.3002353. eCollection 2023 Nov. PLoS Biol. 2023. PMID: 37943878 Free PMC article.
31 results