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Loss of CREBBP and KMT2D cooperate to accelerate lymphomagenesis and shape the lymphoma immune microenvironment.
Li J, Chin CR, Ying HY, Meydan C, Teater MR, Xia M, Farinha P, Takata K, Chu CS, Jiang Y, Eagles J, Passerini V, Tang Z, Rivas MA, Weigert O, Pugh TJ, Chadburn A, Steidl C, Scott DW, Roeder RG, Mason CE, Zappasodi R, Béguelin W, Melnick AM. Li J, et al. Nat Commun. 2024 Apr 3;15(1):2879. doi: 10.1038/s41467-024-47012-1. Nat Commun. 2024. PMID: 38570506 Free PMC article.
Cooperative super-enhancer inactivation caused by heterozygous loss of CREBBP and KMT2D skews B cell fate decisions and yields T cell-depleted lymphomas.
Li J, Chin CR, Ying HY, Meydan C, Teater MR, Xia M, Farinha P, Takata K, Chu CS, Rivas MA, Chadburn A, Steidl C, Scott DW, Roeder RG, Mason CE, Béguelin W, Melnick AM. Li J, et al. bioRxiv [Preprint]. 2023 Feb 13:2023.02.13.528351. doi: 10.1101/2023.02.13.528351. bioRxiv. 2023. PMID: 36824887 Free PMC article. Preprint.