R01 CA057359/CA/NCI NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
1994	1
1995	1
1997	1
1998	1
1999	1
2000	1
2001	1
2002	1
2004	1
2005	1
2006	1
2007	2
2011	1
2012	1
2013	1
2014	2
2015	1
2024	0

1

Inhibition of protein phosphatase 2A (PP2A) prevents Mcl-1 protein dephosphorylation at the Thr-163/Ser-159 phosphodegron, dramatically reducing expression in Mcl-1-amplified lymphoma cells.

Nifoussi SK, Ratcliffe NR, Ornstein DL, Kasof G, Strack S, Craig RW. Nifoussi SK, et al. J Biol Chem. 2014 Aug 8;289(32):21950-9. doi: 10.1074/jbc.M114.587873. Epub 2014 Jun 17. J Biol Chem. 2014. PMID: 24939844 Free PMC article.

2

Inducer-and cell type-specific regulation of antiapoptotic MCL1 in myeloid leukemia and multiple myeloma cells exposed to differentiation-inducing or microtubule-disrupting agents.

Vrana JA, Cleaveland ES, Eastman A, Craig RW. Vrana JA, et al. Apoptosis. 2006 Aug;11(8):1275-88. doi: 10.1007/s10495-006-7787-y. Apoptosis. 2006. PMID: 16761109

3

Acat1 gene ablation in mice increases hematopoietic progenitor cell proliferation in bone marrow and causes leukocytosis.

Huang LH, Gui J, Artinger E, Craig R, Berwin BL, Ernst PA, Chang CC, Chang TY. Huang LH, et al. Arterioscler Thromb Vasc Biol. 2013 Sep;33(9):2081-7. doi: 10.1161/ATVBAHA.112.301080. Epub 2013 Jul 11. Arterioscler Thromb Vasc Biol. 2013. PMID: 23846496 Free PMC article.

4

Dynamic changes in Mcl-1 expression regulate macrophage viability or commitment to apoptosis during bacterial clearance.

Marriott HM, Bingle CD, Read RC, Braley KE, Kroemer G, Hellewell PG, Craig RW, Whyte MK, Dockrell DH. Marriott HM, et al. J Clin Invest. 2005 Feb;115(2):359-68. doi: 10.1172/JCI21766. J Clin Invest. 2005. PMID: 15650769 Free PMC article.

5

MCL1 enhances the survival of CD8+ memory T Cells after viral infection.

Gui J, Hu Z, Tsai CY, Ma T, Song Y, Morales A, Huang LH, Dmitrovsky E, Craig RW, Usherwood EJ. Gui J, et al. J Virol. 2015 Feb;89(4):2405-14. doi: 10.1128/JVI.02480-14. Epub 2014 Dec 10. J Virol. 2015. PMID: 25505074 Free PMC article.

6

N-terminal truncation of antiapoptotic MCL1, but not G2/M-induced phosphorylation, is associated with stabilization and abundant expression in tumor cells.

De Biasio A, Vrana JA, Zhou P, Qian L, Bieszczad CK, Braley KE, Domina AM, Weintraub SJ, Neveu JM, Lane WS, Craig RW. De Biasio A, et al. J Biol Chem. 2007 Aug 17;282(33):23919-36. doi: 10.1074/jbc.M700938200. Epub 2007 Jun 8. J Biol Chem. 2007. PMID: 17561513 Free article.

7

Serine 64 phosphorylation enhances the antiapoptotic function of Mcl-1.

Kobayashi S, Lee SH, Meng XW, Mott JL, Bronk SF, Werneburg NW, Craig RW, Kaufmann SH, Gores GJ. Kobayashi S, et al. J Biol Chem. 2007 Jun 22;282(25):18407-18417. doi: 10.1074/jbc.M610010200. Epub 2007 Apr 25. J Biol Chem. 2007. PMID: 17463001 Free article.

8

MCL1 increases primitive thymocyte viability in female mice and promotes thymic expansion into adulthood.

Gui J, Morales AJ, Maxey SE, Bessette KA, Ratcliffe NR, Kelly JA, Craig RW. Gui J, et al. Int Immunol. 2011 Oct;23(10):647-59. doi: 10.1093/intimm/dxr073. Epub 2011 Sep 21. Int Immunol. 2011. PMID: 21937457 Free PMC article.

9

Thr 163 phosphorylation causes Mcl-1 stabilization when degradation is independent of the adjacent GSK3-targeted phosphodegron, promoting drug resistance in cancer.

Nifoussi SK, Vrana JA, Domina AM, De Biasio A, Gui J, Gregory MA, Hann SR, Craig RW. Nifoussi SK, et al. PLoS One. 2012;7(10):e47060. doi: 10.1371/journal.pone.0047060. Epub 2012 Oct 9. PLoS One. 2012. PMID: 23056582 Free PMC article.

10

MCL1 transgenic mice exhibit a high incidence of B-cell lymphoma manifested as a spectrum of histologic subtypes.

Zhou P, Levy NB, Xie H, Qian L, Lee CY, Gascoyne RD, Craig RW. Zhou P, et al. Blood. 2001 Jun 15;97(12):3902-9. doi: 10.1182/blood.v97.12.3902. Blood. 2001. PMID: 11389033 Free article.

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