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Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1.
Nature. 2009 Nov 5;462(7269):108-12. doi: 10.1038/nature08460. Epub 2009 Oct 21.
Nature. 2009.
PMID: 19847166
Free PMC article.
An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1.
Thoreen CC, Kang SA, Chang JW, Liu Q, Zhang J, Gao Y, Reichling LJ, Sim T, Sabatini DM, Gray NS.
Thoreen CC, et al.
J Biol Chem. 2009 Mar 20;284(12):8023-32. doi: 10.1074/jbc.M900301200. Epub 2009 Jan 15.
J Biol Chem. 2009.
PMID: 19150980
Free PMC article.
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Rapamycin inhibits mTORC1, but not completely.
Thoreen CC, Sabatini DM.
Thoreen CC, et al.
Autophagy. 2009 Jul;5(5):725-6. doi: 10.4161/auto.5.5.8504. Epub 2009 Jul 22.
Autophagy. 2009.
PMID: 19395872
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DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival.
Peterson TR, Laplante M, Thoreen CC, Sancak Y, Kang SA, Kuehl WM, Gray NS, Sabatini DM.
Peterson TR, et al.
Cell. 2009 May 29;137(5):873-86. doi: 10.1016/j.cell.2009.03.046. Epub 2009 May 14.
Cell. 2009.
PMID: 19446321
Free PMC article.
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