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An undesired effect of chemotherapy: gemcitabine promotes pancreatic cancer cell invasiveness through reactive oxygen species-dependent, nuclear factor κB- and hypoxia-inducible factor 1α-mediated up-regulation of CXCR4.
Arora S, Bhardwaj A, Singh S, Srivastava SK, McClellan S, Nirodi CS, Piazza GA, Grizzle WE, Owen LB, Singh AP. Arora S, et al. J Biol Chem. 2013 Jul 19;288(29):21197-21207. doi: 10.1074/jbc.M113.484576. Epub 2013 Jun 5. J Biol Chem. 2013. PMID: 23740244 Free PMC article.