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A novel protein-engineered hepatocyte growth factor analog released via a shear-thinning injectable hydrogel enhances post-infarction ventricular function.
Steele AN, Cai L, Truong VN, Edwards BB, Goldstone AB, Eskandari A, Mitchell AC, Marquardt LM, Foster AA, Cochran JR, Heilshorn SC, Woo YJ. Steele AN, et al. Biotechnol Bioeng. 2017 Oct;114(10):2379-2389. doi: 10.1002/bit.26345. Epub 2017 Jun 29. Biotechnol Bioeng. 2017. PMID: 28574594 Free PMC article.
Multi-phase catheter-injectable hydrogel enables dual-stage protein-engineered cytokine release to mitigate adverse left ventricular remodeling following myocardial infarction in a small animal model and a large animal model.
Steele AN, Paulsen MJ, Wang H, Stapleton LM, Lucian HJ, Eskandari A, Hironaka CE, Farry JM, Baker SW, Thakore AD, Jaatinen KJ, Tada Y, Hollander MJ, Williams KM, Seymour AJ, Totherow KP, Yu AC, Cochran JR, Appel EA, Woo YJ. Steele AN, et al. Cytokine. 2020 Mar;127:154974. doi: 10.1016/j.cyto.2019.154974. Epub 2020 Jan 21. Cytokine. 2020. PMID: 31978642
Delivery of an engineered HGF fragment in an extracellular matrix-derived hydrogel prevents negative LV remodeling post-myocardial infarction.
Sonnenberg SB, Rane AA, Liu CJ, Rao N, Agmon G, Suarez S, Wang R, Munoz A, Bajaj V, Zhang S, Braden R, Schup-Magoffin PJ, Kwan OL, DeMaria AN, Cochran JR, Christman KL. Sonnenberg SB, et al. Biomaterials. 2015 Mar;45:56-63. doi: 10.1016/j.biomaterials.2014.12.021. Epub 2015 Jan 13. Biomaterials. 2015. PMID: 25662495 Free PMC article.