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Page 1
BCL10 Mutations Define Distinct Dependencies Guiding Precision Therapy for DLBCL.
Xia M, David L, Teater M, Gutierrez J, Wang X, Meydan C, Lytle A, Slack GW, Scott DW, Morin RD, Onder O, Elenitoba-Johnson KSJ, Zamponi N, Cerchietti L, Lu T, Philippar U, Fontan L, Wu H, Melnick AM. Xia M, et al. Cancer Discov. 2022 Aug 5;12(8):1922-1941. doi: 10.1158/2159-8290.CD-21-1566. Cancer Discov. 2022. PMID: 35658124 Free PMC article.
Peptide-based covalent inhibitors of MALT1 paracaspase.
Hatcher JM, Du G, Fontán L, Us I, Qiao Q, Chennamadhavuni S, Shao J, Wu H, Melnick A, Gray NS, Scott DA. Hatcher JM, et al. Bioorg Med Chem Lett. 2019 Jun 1;29(11):1336-1339. doi: 10.1016/j.bmcl.2019.03.046. Epub 2019 Mar 29. Bioorg Med Chem Lett. 2019. PMID: 30954428
Quinoline and thiazolopyridine allosteric inhibitors of MALT1.
Scott DA, Hatcher JM, Liu H, Fu M, Du G, Fontán L, Us I, Casalena G, Qiao Q, Wu H, Melnick A, Gray NS. Scott DA, et al. Bioorg Med Chem Lett. 2019 Jul 15;29(14):1694-1698. doi: 10.1016/j.bmcl.2019.05.040. Epub 2019 May 20. Bioorg Med Chem Lett. 2019. PMID: 31129051
Specific covalent inhibition of MALT1 paracaspase suppresses B cell lymphoma growth.
Fontán L, Qiao Q, Hatcher JM, Casalena G, Us I, Teater M, Durant M, Du G, Xia M, Bilchuk N, Chennamadhavuni S, Palladino G, Inghirami G, Philippar U, Wu H, Scott DA, Gray NS, Melnick A. Fontán L, et al. J Clin Invest. 2018 Oct 1;128(10):4397-4412. doi: 10.1172/JCI99436. Epub 2018 Jul 19. J Clin Invest. 2018. PMID: 30024860 Free PMC article.