R01 CA244144/CA/NCI NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2020	5
2021	16
2022	13
2023	10
2024	10

1

Targeting ferroptosis as a vulnerability in cancer.

Lei G, Zhuang L, Gan B. Lei G, et al. Nat Rev Cancer. 2022 Jul;22(7):381-396. doi: 10.1038/s41568-022-00459-0. Epub 2022 Mar 25. Nat Rev Cancer. 2022. PMID: 35338310 Free PMC article. Review.

2

Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy.

Koppula P, Zhuang L, Gan B. Koppula P, et al. Protein Cell. 2021 Aug;12(8):599-620. doi: 10.1007/s13238-020-00789-5. Epub 2020 Oct 1. Protein Cell. 2021. PMID: 33000412 Free PMC article. Review.

3

Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis.

Liu X, Nie L, Zhang Y, Yan Y, Wang C, Colic M, Olszewski K, Horbath A, Chen X, Lei G, Mao C, Wu S, Zhuang L, Poyurovsky MV, James You M, Hart T, Billadeau DD, Chen J, Gan B. Liu X, et al. Nat Cell Biol. 2023 Mar;25(3):404-414. doi: 10.1038/s41556-023-01091-2. Epub 2023 Feb 6. Nat Cell Biol. 2023. PMID: 36747082 Free PMC article.

4

Mitochondrial regulation of ferroptosis.

Gan B. Gan B. J Cell Biol. 2021 Sep 6;220(9):e202105043. doi: 10.1083/jcb.202105043. Epub 2021 Jul 30. J Cell Biol. 2021. PMID: 34328510 Free PMC article. Review.

5

DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer.

Mao C, Liu X, Zhang Y, Lei G, Yan Y, Lee H, Koppula P, Wu S, Zhuang L, Fang B, Poyurovsky MV, Olszewski K, Gan B. Mao C, et al. Nature. 2021 May;593(7860):586-590. doi: 10.1038/s41586-021-03539-7. Epub 2021 May 12. Nature. 2021. PMID: 33981038 Free PMC article.

6

A targetable CoQ-FSP1 axis drives ferroptosis- and radiation-resistance in KEAP1 inactive lung cancers.

Koppula P, Lei G, Zhang Y, Yan Y, Mao C, Kondiparthi L, Shi J, Liu X, Horbath A, Das M, Li W, Poyurovsky MV, Olszewski K, Gan B. Koppula P, et al. Nat Commun. 2022 Apr 22;13(1):2206. doi: 10.1038/s41467-022-29905-1. Nat Commun. 2022. PMID: 35459868 Free PMC article.

7

Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer.

Liu X, Olszewski K, Zhang Y, Lim EW, Shi J, Zhang X, Zhang J, Lee H, Koppula P, Lei G, Zhuang L, You MJ, Fang B, Li W, Metallo CM, Poyurovsky MV, Gan B. Liu X, et al. Nat Cell Biol. 2020 Apr;22(4):476-486. doi: 10.1038/s41556-020-0496-x. Epub 2020 Mar 30. Nat Cell Biol. 2020. PMID: 32231310 Free PMC article.

8

Ferroptosis hijacking by Mycobacterium tuberculosis.

Gan B. Gan B. Nat Commun. 2023 Mar 17;14(1):1431. doi: 10.1038/s41467-023-37149-w. Nat Commun. 2023. PMID: 36932073 Free PMC article.

9

SLC7A11 expression level dictates differential responses to oxidative stress in cancer cells.

Yan Y, Teng H, Hang Q, Kondiparthi L, Lei G, Horbath A, Liu X, Mao C, Wu S, Zhuang L, James You M, Poyurovsky MV, Ma L, Olszewski K, Gan B. Yan Y, et al. Nat Commun. 2023 Jun 21;14(1):3673. doi: 10.1038/s41467-023-39401-9. Nat Commun. 2023. PMID: 37339981 Free PMC article.

10

mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation.

Zhang Y, Swanda RV, Nie L, Liu X, Wang C, Lee H, Lei G, Mao C, Koppula P, Cheng W, Zhang J, Xiao Z, Zhuang L, Fang B, Chen J, Qian SB, Gan B. Zhang Y, et al. Nat Commun. 2021 Mar 11;12(1):1589. doi: 10.1038/s41467-021-21841-w. Nat Commun. 2021. PMID: 33707434 Free PMC article.

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