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Metabolic adaptations through the PGC-1 alpha and SIRT1 pathways.
FEBS Lett. 2008 Jan 9;582(1):46-53. doi: 10.1016/j.febslet.2007.11.034. Epub 2007 Nov 26.
FEBS Lett. 2008.
PMID: 18036349
Free PMC article.
Review.
Nutrient-dependent regulation of PGC-1alpha's acetylation state and metabolic function through the enzymatic activities of Sirt1/GCN5.
Dominy JE Jr, Lee Y, Gerhart-Hines Z, Puigserver P.
Dominy JE Jr, et al.
Biochim Biophys Acta. 2010 Aug;1804(8):1676-83. doi: 10.1016/j.bbapap.2009.11.023. Epub 2009 Dec 11.
Biochim Biophys Acta. 2010.
PMID: 20005308
Free PMC article.
Review.
Item in Clipboard
Cdc2-like kinase 2 is an insulin-regulated suppressor of hepatic gluconeogenesis.
Rodgers JT, Haas W, Gygi SP, Puigserver P.
Rodgers JT, et al.
Cell Metab. 2010 Jan;11(1):23-34. doi: 10.1016/j.cmet.2009.11.006.
Cell Metab. 2010.
PMID: 20074525
Free PMC article.
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Hypothalamic malonyl-CoA triggers mitochondrial biogenesis and oxidative gene expression in skeletal muscle: Role of PGC-1alpha.
Cha SH, Rodgers JT, Puigserver P, Chohnan S, Lane MD.
Cha SH, et al.
Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15410-5. doi: 10.1073/pnas.0607334103. Epub 2006 Oct 9.
Proc Natl Acad Sci U S A. 2006.
PMID: 17030788
Free PMC article.
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The cAMP/PKA pathway rapidly activates SIRT1 to promote fatty acid oxidation independently of changes in NAD(+).
Gerhart-Hines Z, Dominy JE Jr, Blättler SM, Jedrychowski MP, Banks AS, Lim JH, Chim H, Gygi SP, Puigserver P.
Gerhart-Hines Z, et al.
Mol Cell. 2011 Dec 23;44(6):851-63. doi: 10.1016/j.molcel.2011.12.005.
Mol Cell. 2011.
PMID: 22195961
Free PMC article.
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