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The Ngal reporter mouse detects the response of the kidney to injury in real time.
Paragas N, Qiu A, Zhang Q, Samstein B, Deng SX, Schmidt-Ott KM, Viltard M, Yu W, Forster CS, Gong G, Liu Y, Kulkarni R, Mori K, Kalandadze A, Ratner AJ, Devarajan P, Landry DW, D'Agati V, Lin CS, Barasch J. Paragas N, et al. Nat Med. 2011 Feb;17(2):216-22. doi: 10.1038/nm.2290. Epub 2011 Jan 16. Nat Med. 2011. PMID: 21240264 Free PMC article.
Iron traffics in circulation bound to a siderocalin (Ngal)-catechol complex.
Bao G, Clifton M, Hoette TM, Mori K, Deng SX, Qiu A, Viltard M, Williams D, Paragas N, Leete T, Kulkarni R, Li X, Lee B, Kalandadze A, Ratner AJ, Pizarro JC, Schmidt-Ott KM, Landry DW, Raymond KN, Strong RK, Barasch J. Bao G, et al. Nat Chem Biol. 2010 Aug;6(8):602-9. doi: 10.1038/nchembio.402. Epub 2010 Jun 27. Nat Chem Biol. 2010. PMID: 20581821 Free PMC article.
Diagnostic and prognostic stratification in the emergency department using urinary biomarkers of nephron damage: a multicenter prospective cohort study.
Nickolas TL, Schmidt-Ott KM, Canetta P, Forster C, Singer E, Sise M, Elger A, Maarouf O, Sola-Del Valle DA, O'Rourke M, Sherman E, Lee P, Geara A, Imus P, Guddati A, Polland A, Rahman W, Elitok S, Malik N, Giglio J, El-Sayegh S, Devarajan P, Hebbar S, Saggi SJ, Hahn B, Kettritz R, Luft FC, Barasch J. Nickolas TL, et al. J Am Coll Cardiol. 2012 Jan 17;59(3):246-55. doi: 10.1016/j.jacc.2011.10.854. J Am Coll Cardiol. 2012. PMID: 22240130 Free PMC article.