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Stress-induced pseudokinase TRB3 augments IL1β signaling by interacting with Flightless homolog 1.
J Biol Chem. 2023 Aug;299(8):104803. doi: 10.1016/j.jbc.2023.104803. Epub 2023 May 11.
J Biol Chem. 2023.
PMID: 37172723
Free PMC article.
Nutrient regulation of the islet epigenome controls adaptive insulin secretion.
Wortham M, Liu F, Harrington AR, Fleischman JY, Wallace M, Mulas F, Mallick M, Vinckier NK, Cross BR, Chiou J, Patel NA, Sui Y, McGrail C, Jun Y, Wang G, Jhala US, Schüle R, Shirihai OS, Huising MO, Gaulton KJ, Metallo CM, Sander M.
Wortham M, et al.
J Clin Invest. 2023 Apr 17;133(8):e165208. doi: 10.1172/JCI165208.
J Clin Invest. 2023.
PMID: 36821378
Free PMC article.
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LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development.
Vinckier NK, Patel NA, Geusz RJ, Wang A, Wang J, Matta I, Harrington AR, Wortham M, Wetton N, Wang J, Jhala US, Rosenfeld MG, Benner CW, Shih HP, Sander M.
Vinckier NK, et al.
Nat Commun. 2020 Apr 29;11(1):2082. doi: 10.1038/s41467-020-16017-x.
Nat Commun. 2020.
PMID: 32350257
Free PMC article.
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Loss of TRB3 alters dynamics of MLK3-JNK signaling and inhibits cytokine-activated pancreatic beta cell death.
Humphrey RK, Ray A, Gonuguntla S, Hao E, Jhala US.
Humphrey RK, et al.
J Biol Chem. 2014 Oct 24;289(43):29994-30004. doi: 10.1074/jbc.M114.575613. Epub 2014 Sep 9.
J Biol Chem. 2014.
PMID: 25204656
Free PMC article.
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Glucose regulates steady-state levels of PDX1 via the reciprocal actions of GSK3 and AKT kinases.
Humphrey RK, Yu SM, Flores LE, Jhala US.
Humphrey RK, et al.
J Biol Chem. 2010 Jan 29;285(5):3406-16. doi: 10.1074/jbc.M109.006734. Epub 2009 Oct 15.
J Biol Chem. 2010.
PMID: 19833727
Free PMC article.
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Mixed lineage kinase-3 stabilizes and functionally cooperates with TRIBBLES-3 to compromise mitochondrial integrity in cytokine-induced death of pancreatic beta cells.
Humphrey RK, Newcomb CJ, Yu SM, Hao E, Yu D, Krajewski S, Du K, Jhala US.
Humphrey RK, et al.
J Biol Chem. 2010 Jul 16;285(29):22426-36. doi: 10.1074/jbc.M110.123786. Epub 2010 Apr 26.
J Biol Chem. 2010.
PMID: 20421299
Free PMC article.
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Lysine 63-linked ubiquitination modulates mixed lineage kinase-3 interaction with JIP1 scaffold protein in cytokine-induced pancreatic β cell death.
Humphrey RK, Yu SM, Bellary A, Gonuguntla S, Yebra M, Jhala US.
Humphrey RK, et al.
J Biol Chem. 2013 Jan 25;288(4):2428-40. doi: 10.1074/jbc.M112.425884. Epub 2012 Nov 21.
J Biol Chem. 2013.
PMID: 23172226
Free PMC article.
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