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Mechanisms of adhesion G protein-coupled receptor activation.
Vizurraga A, Adhikari R, Yeung J, Yu M, Tall GG. Vizurraga A, et al. J Biol Chem. 2020 Oct 9;295(41):14065-14083. doi: 10.1074/jbc.REV120.007423. Epub 2020 Aug 6. J Biol Chem. 2020. PMID: 32763969 Free PMC article. Review.
The tethered peptide activation mechanism of adhesion GPCRs.
Barros-Álvarez X, Nwokonko RM, Vizurraga A, Matzov D, He F, Papasergi-Scott MM, Robertson MJ, Panova O, Yardeni EH, Seven AB, Kwarcinski FE, Su H, Peroto MC, Meyerowitz JG, Shalev-Benami M, Tall GG, Skiniotis G. Barros-Álvarez X, et al. Nature. 2022 Apr;604(7907):757-762. doi: 10.1038/s41586-022-04575-7. Epub 2022 Apr 13. Nature. 2022. PMID: 35418682 Free PMC article.
GPR56/ADGRG1 is associated with response to antidepressant treatment.
Belzeaux R, Gorgievski V, Fiori LM, Lopez JP, Grenier J, Lin R, Nagy C, Ibrahim EC, Gascon E, Courtet P, Richard-Devantoy S, Berlim M, Chachamovich E, Théroux JF, Dumas S, Giros B, Rotzinger S, Soares CN, Foster JA, Mechawar N, Tall GG, Tzavara ET, Kennedy SH, Turecki G. Belzeaux R, et al. Nat Commun. 2020 Apr 2;11(1):1635. doi: 10.1038/s41467-020-15423-5. Nat Commun. 2020. PMID: 32242018 Free PMC article. Clinical Trial.
G12/13 is activated by acute tethered agonist exposure in the adhesion GPCR ADGRL3.
Mathiasen S, Palmisano T, Perry NA, Stoveken HM, Vizurraga A, McEwen DP, Okashah N, Langenhan T, Inoue A, Lambert NA, Tall GG, Javitch JA. Mathiasen S, et al. Nat Chem Biol. 2020 Dec;16(12):1343-1350. doi: 10.1038/s41589-020-0617-7. Epub 2020 Aug 10. Nat Chem Biol. 2020. PMID: 32778842 Free PMC article.
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